Immune Checkpoint Molecules May Serve as Markers of AAV Activity

Blood levels of the soluble forms of CD28 and TIM-3 — two receptor proteins involved in the regulation of immune responses — are significantly associated with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) activity, a study showed. The levels of these so-called immune checkpoint molecules were increased in people with active AAV…

What do you do when life as you know it and as you’ve dreamed about ceases to exist? That was the question I had to answer at 21 years old. Six months before that late-evening “Are you sitting down?” call from two of my doctors, I would’ve never imagined that…

Hepatitis E infection can be effectively managed in people with ANCA-associated vasculitis (AAV) by pausing immunosuppressive therapy, though patients may experience AAV flares during this pause, a new study shows. “Despite potent immunosuppression before infection, all patients cleared the virus after cessation of the immunosuppressant without additional anti-viral therapy.

A 13-year-old girl developed ANCA-associated vasculitis (AAV) with major involvement of the central nervous system after COVID-19, a case study reports. “To our knowledge, this is the first reported pediatric case of ANCA-associated vasculitis with predominant central nervous system involvement after COVID-19 infection,” the researchers wrote. The girl had…

A 25-year-old man was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA) after going to an outpatient clinic with joint pain and numbness in the hands and legs, according to a case study. He received treatment with corticosteroids and immunosuppressants, which stopped the EGPA progression and eased peripheral…

Sometimes the simplest things turn out to have an enormous impact. Vasculitis patients know the value in life’s beautiful details that others may take for granted, such as a stable routine, supportive friends, or a day of the week when our symptoms are quiet. Even though I’ve been…

The CoronaVac COVID-19 vaccine has an excellent safety profile, but generates only a moderate immune response in people with ANCA-associated vasculitis (AAV), a clinical trial analysis found. Although the levels of vaccine-induced antibodies against SARS-CoV-2, the virus that causes COVID-19, declined over six months, a booster shot was shown…

Monocytes, a type of white blood cell, that carry a protein called CD206 are found at abnormally high levels in the blood of people with active ANCA-associated vasculitis (AAV), a study has found. This held true even when researchers compared people with AAV who had glomerulonephritis, a condition in…

Patients with active ANCA-associated vasculitis (AAV) can be distinguished from those who are in remission by the presence of different subsets of a type of immune cell known as regulatory T-cells, or Tregs, a new study reported. Reduced functionality of these regulatory immune cells had been previously implicated in…

People with ANCA-associated vasculitis (AAV) are at an increased risk of experiencing cardiovascular problems, such as a stroke, according to a new study done in South Korea. Indeed, AAV patients were found to have a more than two times higher risk of cardiovascular health problems than individuals without any…