Author Archives: Margarida Maia

Tofacitinib Seen as Effective and Safe for AAV Patients in Pilot Study

Treatment with tofacitinib is well tolerated and effectively induces remission in people with ANCA-associated vasculitis (AAV), while enabling patients to lower their glucocorticoid doses, a small pilot study suggests. These results indicate that tofacitinib may represent a treatment option for active AAV. However, a larger and randomized controlled trial is needed…

Using Rituximab Long-term May Cause Inflammatory Vaginitis

Inflammatory vaginitis — inflammation of the vagina — may develop in women receiving long-term treatment with rituximab for ANCA-associated vasculitis (AAV) or other autoimmune diseases, a U.S. study says. The findings suggest that “women treated with rituximab should be screened for symptoms such as vaginal discharge and vaginal pain,” its…

Mycophenolate Mofetil Can Effectively Induce Remission in EGPA

Mycophenolate mofetil (MMF) is well-tolerated and can be used to induce remission in people with eosinophilic granulomatosis with polyangiitis (EGPA), a type of ANCA-associated vasculitis (AAV), a real-world study shows. Two-thirds of patients with newly diagnosed or relapsing EGPA achieved remission, or had no symptoms appearing for a time,…

Rituximab Found to Be Safe, Effective for 2 AAV Types in Children

Rituximab is safe and effective for inducing remission in two types of ANCA-associated vasculitis in children and adolescents: granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA), according to data from a Phase 2a trial. After one and a half years on the trial, all patients achieved remission, and safety…

Certain Immune Cells May Help Assess AAV Disease Activity

A blood parameter called large unstained cell count or LUC – which measures the numbers of certain activated immune cells – appears to associate with higher ANCA-associated vasculitis (AAV) disease activity, a small study found. These results, when combined with the findings of previous, larger-scale studies, show that “LUC…

Most Adhered to Treatment During COVID-19 Lockdowns

About one-third of patients with ANCA-associated vasculitis (AAV) or other forms of vasculitis postponed at least one of their healthcare visits during the first months of the COVID-19 pandemic, but most continued adhering to treatment, a survey reveals. Moreover, patients with vasculitis are complying with advice to stay at…