Rituximab is superior to other immunosuppressive treatments at preventing post-surgery relapse in granulomatosis with polyangiitis (GPA) patients undergoing surgery to address subglottic stenosis, a common complication that causes airway narrowing. That’s according to a study that analyzed data from 25 GPA patients who were followed for more than…
Rituximab cuts recurrence risk in subglottic stenosis surgery: Study
Ioana Miclea has eosinophilic granulomatosis with polyangiitis. (Photos courtesy of Ioana Miclea) This is Ioana Miclea’s story. So, picture this: I’m Ioana, your quintessential 20-something girl, living it up with nights out, camping escapades, and a newfound love for festivals. And I’m jamming out to some meme song I…
Amgen is planning to launch a Phase 3 clinical trial testing Tavneos (avacopan) — its approved therapy for adults with ANCA-associated vasculitis (AAV) — in combination with a standard regimen of rituximab or cyclophosphamide in children and adolescents with active AAV. That’s according to a company press release…
Janice Barnett poses with a textile piece in the making. (Photos courtesy of Janice Barnett) This is Janice Barnett’s story: My diagnosis of eosinophilic granulomatosis with polyangiitis, formerly known as Churg-Strauss syndrome, in December 2021 plunged me into a state of utter disbelief. I was fit and…
Rachel Young learns to walk again in 2022. (Photos courtesy of Rachel Young) This is Rachel Young’s story: Young hikes in 2023. If I had ever heard the term “vasculitis” before my diagnosis three years ago (ANCA vasculitis with kidney involvement), it wasn’t something that held…
May will be an activity-filled month for people living with vasculitis — and for doctors, researchers, and advocates in the field — as the world recognizes Vasculitis Awareness Month (VAM), and International Vasculitis Day on May 15. Vasculitis is a group of rare autoimmune diseases characterized by inflammation and damage…
Lower blood counts of platelets — tiny cell fragments involved in blood clotting — at the time that ANCA-associated vasculitis (AAV) is diagnosed may be a marker of poorer kidney function and a higher risk of kidney failure, according to a retrospective study from China. Findings suggest that “platelet…
Men with ANCA-associated vasculitis (AAV) are three times more likely to develop cancer, most often that affecting the lungs and the head and neck, than age-matched men in the Turkish population, a study based on patient registry data found. Older age — age 60 or older — at AAV…
The risk of poor outcomes after a kidney transplant is considerably higher for ANCA-associated vasculitis (AAV) patients with kidney failure than people without the autoimmune disease, ranging from infections and disease relapse to death, a review study reports. But long-term survival rates for those who make it through the…
Tavneos (avacopan) safely and effectively promotes clinical remission in people with newly diagnosed or relapsing ANCA-associated vasculitis (AAV), according to a multicenter, real-world study in the U.S. The remission rates after a year of treatment were higher than those in the Phase 3 ADVOCATE trial (NCT02994927), whose…
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