Melodia Therapeutics has acquired the exclusive rights to develop, manufacture, and commercialize MDI-0151, a candidate therapy for hard-to-treat ANCA-associated vasculitis (AAV) and other disorders marked by overactivation of neutrophils, a type of immune cell. Melodia said it will “rapidly initiate” investigational new drug (IND)-enabling studies in preparation of a…
Melodia buys rights to potential AAV therapy MDI-0151
The U.S. Food and Drug Administration (FDA) has given NovelMed the green light to initiate a Phase 2 clinical trial to test its investigational antibody-based therapy ruxoprubart in adults with ANCA-associated vasculitis (AAV). The Phase 2 study (NCT06226662) will evaluate the therapy’s safety and efficacy in up…
Inflammatory bowel disease (IBD) — a chronic disease where the bowel becomes inflamed, causing recurring lower abdominal pain and diarrhea — can overlap with ANCA-associated vasculitis (AAV) and is often diagnosed first, a study found. The finding suggests a possible link between the two diseases, and that having IBD…
Symptoms and disease manifestations of eosinophilic granulomatosis with polyangiitis (EGPA), a rare type of ANCA-associated vasculitis (AAV), are generally similar between patients with and without ANCAs, the self-reactive antibodies that drive most AAV cases. That’s according to a study analyzing data from a registry of people with vasculitis, or…
Sinonasal manifestations — those encompassing the nose and the paranasal sinuses, or the air-filled cavities around the nose — in granulomatosis with polyangiitis (GPA) vary among patients, based on disease activity and duration. That’s according to a small, retrospective study of GPA patients with sinonasal manifestations seen at a…
About 1 in every 5 people with ANCA-associated vasculitis (AAV), at some point in life, may experience problems that keep the thyroid gland from making the right amount of hormones, with these problems most often developing within five years of an AAV diagnosis, a large study found. While…
Christine MacFadyen’s symptoms appeared 15 years ago, and she was diagnosed five years ago. (Photos courtesy of Christine MacFadyen) This is Christine MacFadyen’s story: I was a fun-loving, always smiling, energetic, adventurous woman. I was only 24 and had just graduated with my college degree in early childhood care…
High blood levels of the protein CX3CL1, a pro-inflammatory immune signal that appears to be associated with blood vessel inflammation, can accurately discriminate microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) patients with active disease from those without, a study found. Importantly, high CX3CL1 levels were found to increase the…
Sarah Wellings, left, smiles with Isla Bell before her ANCA vasculitis diagnosis. (Photos courtesy of Sarah Wellings) This is Sarah Wellings’ story: Last night I dreamed I was running again. It seems my running days are over. Don’t get me wrong, I was no athlete when I was healthy,…
Jennifer Feinson Destours is an American with ANCA vasculitis living in Paris. This photo was taken two years post-diagnosis. (Photos courtesy of Jennifer Feinson Destours) This is Jennifer Feinson Destours’ story: My life has often been fantasized, the subject of envy. It sounds great, doesn’t it? An American moves…
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