Tavneos (avacopan) safely and effectively promotes clinical remission in people with newly diagnosed or relapsing ANCA-associated vasculitis (AAV), according to a multicenter, real-world study in the U.S. The remission rates after a year of treatment were higher than those in the Phase 3 ADVOCATE trial (NCT02994927), whose…
Occupational exposure to silica, one of the most common minerals in the earth’s crust, may lead to microscopic polyangiitis (MPA) — a type of ANCA-associated vasculitis — particularly in individuals with a genetic predisposition to autoimmune diseases, a case report suggests. Silica, found in sand and rocks, is known to…
ANCA-associated vasculitis (AAV) relapses occur more frequently during the summer and spring, particularly for people with granulomatosis with polyangiitis (GPA) or with anti-proteinase 3 (PR3) antibodies, a study in Japan reports. More frequent nasal infections caused by the bacterium Staphylococcus aureus during the summer in Japan may trigger inflammation…
A 64-year-old man with severe granulomatosis with polyangiitis (GPA) saw his condition improve with the use of a triple combination of standard cyclophosphamide and glucocorticoids along with the experimental therapy telitacicept, according to a case report from China. RemeGen’s telitacicept is approved in China under the brand name…
The severity of anemia, or low levels of oxygen-carrying hemoglobin, is significantly associated with certain kidney lesions in people with ANCA-associated vasculitis (AAV) and kidney involvement, a study showed. These findings “reflect an additional aspect of anemia pathophysiology [disease mechanisms] in ANCA-associated renal vasculitis,” the researchers wrote. The study,…
Treatment with rituximab has a similar efficacy to cyclophosphamide — both of them standard immunosuppressive therapies — in reducing short-time mortality in adults with life-threatening ANCA-associated vasculitis (AAV), a study in Japan found. Moreover, rituximab was associated with a significantly lower risk of fungal infections relative to cyclophosphamide. However,…
Intravenous immunoglobulin (IVIG) therapy appears to be an effective and relatively safe option for people with ANCA-associated vasculitis (AAV), according to real-life study of its use in Spain. All of its 28 AAV patients were resistant to conventional treatments and/or had — or were suspected of having — an…
Among people with ANCA-associated vasculitis (AAV), those with central diabetes insipidus are more frequently diagnosed with granulomatosis with polyangiitis (GPA), a type of AAV, according to a study in China. Central diabetes insipidus, or CDI, is a rare disease characterized by excessive thirst and excessive urine. Patients with…
Researchers in Korea have identified a new index that can predict all-cause mortality in non-obese people with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The index accounts for blood levels of fatty molecules called triglycerides and blood sugar, as well as body mass index (BMI, a ratio of height and…
Daratumumab helped in the remission of severe lung and skin symptoms in a young man with granulomatosis with polyangiitis (GPA), a type of ANCA–associated vasculitis (AAV), scientists in Germany report. An immunotherapy approved to treat multiple myeloma (sold as Darzalex), daratumumab was added after the patient failed to respond…
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