Being frail, that is, more vulnerable to health stressors as a result of aging-related biological changes, may put older adults with ANCA-associated vasculitis (AAV) at higher risk of developing severe infections, a study in the U.S. suggests. Being age 75 or older, but not frail, was linked to a…
Most children with granulomatosis with polyangiitis (GPA) have respiratory manifestations including cough and shortness of breath at diagnosis, and these frequently persist or relapse, according to a study in the U.S. involving 13 pediatric patients. Lung abnormalities were detected in nearly all children with available imaging data at diagnosis…
People with ANCA-associated vasculitis (AAV) who carry certain variants in SERPINA1 — a gene that’s been previously linked to the autoimmune disease — may have a six times higher risk of death than those without such variants. That’s according to new data from a single-center study in Brazil, in…
Treatment with rituximab in children with ANCA-associated vasculitis (AAV) is at least non-inferior to the use of cyclophosphamide at inducing disease remission or low disease activity among pediatric patients, according to data from a large international observational study. The researchers noted that rituximab treatment was associated with greater…
People with ANCA-associated vasculitis (AAV) have a higher frequency of thyroid diseases, that is, those that affect the hormone-production function of the thyroid gland, than the general population, a study in China suggests. Being female, having coronary artery disease, which is marked by reduced blood flow in the arteries…
Low blood levels of glial fibrillary acidic protein (GFAP) are linked to more active disease and a higher risk of kidney failure in newly diagnosed ANCA-associated vasculitis (AAV), a study finds. The findings point to GFAP as a potential blood biomarker to predict the course of AAV early and…
Self-reactive antibodies, or autoantibodies, against two proteins — homeostatic iron regulator, or HFE, and synaptotagmin 5, known as SYT5 — appear to be linked to a higher risk of relapse among people with ANCA-associated vasculitis (AAV), according to a new study. These findings suggest that the presence of abnormal…
A new Phase 3 clinical trial is recruiting children and adolescents with active granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA), the most common types of ANCA-associated vasculitis (AAV), to test Tavneos (avacopan) in combination with rituximab or cyclophosphamide. That’s according to a financial update released by…
Fasenra (benralizumab) has been granted approval in the European Union as an add-on treatment for adults with relapsing or treatment-resistant eosinophilic granulomatosis with polyangiitis, or EGPA, a rare type of ANCA-associated vasculitis (AAV). The clearance of Fasenra, “with its convenient, single-monthly injection is a positive step forward…
Combination maintenance therapy with Nucala (mepolizumab) and azathioprine may be more effective than either treatment alone at maintaining disease remission and reducing the need for glucocorticoids in people with severe eosinophilic granulomatosis with polyangiitis (EGPA). These are the findings of a single-center study in Japan that support the use…
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