News

Blinatumomab, a blood cancer treatment, improved kidney function in two people newly diagnosed with ANCA-associated vasculitis (AAV) and rapidly progressive glomerulonephritis (RPGN), or inflammation in the kidney’s filtering units, a study shows. The therapy is designed to promote an interaction between immune T-cells, which can kill other cells, and…

Adults with ANCA-associated vasculitis (AAV) who experience a relapse after stopping maintenance therapy show a distinct gene activity signature in their blood compared with those who are newly diagnosed or in remission, a study shows. The results point specifically to genes that control the release of pro-inflammatory molecules from…

Alentis Therapeutics and CSL are joining forces to develop and commercialize lixudebart, an infusion treatment candidate for people with ANCA-associated vasculitis (AAV) who also have rapidly progressive glomerulonephritis (RPGN), a severe form of kidney damage. The partnership joins Alentis‘ expertise as lixudebart’s original developer with CSL‘s…

Orbital MRI scans, which assess the tissues surrounding the eyes, may help differentiate granulomatosis with polyangiitis (GPA) from other conditions affecting the eye socket, a new study demonstrates. “From a clinical perspective, [the identified] imaging features can help differentiate GPA from its mimics, guide timely biopsy decisions, and support…

A type of artificial intelligence (AI) identified three main forms of eosinophilic granulomatosis with polyangiitis (EGPA), each characterized by distinct biological changes and disease manifestations, according to a new study. Findings suggest that the three groups may also differ in how patients respond to treatment. Although further work…

A type of artificial intelligence (AI) called ensemble clustering identified four distinct patterns of organ involvement in ANCA-associated vasculitis (AAV) that were associated with differences in survival and relapse rates, a study showed. The pattern dominated by ear, nose, and throat (ENT) involvement was associated with the highest survival…

Elevated activity of genes of the complement pathway, a part of the immune system, in kidney tissue is associated with impaired kidney function and inflammation in adults with ANCA-associated vasculitis (AAV) and related kidney disease, a study shows. Despite these findings, results from blood tests or tissue staining analysis…

Hospitalization rates for ANCA-associated vasculitis (AAV) vary substantially from one country to another, according to a multinational study. Researchers examined hospital records from eight countries, including the U.S., between 2016 and 2022 and found that rates, subtypes, and in-hospital death proportions differed markedly, with Germany and England reporting the…

People with the two most common types of ANCA-associated vasculitis (AAV) face a substantially higher risk of cardiovascular disease and thromboembolism (blood clots) than the general population, according to a nationwide Swedish analysis. The study, which compared over 4,000 patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA)…

One in seven people with ANCA-associated vasculitis (AAV) has renal arteritis, or inflammation of the small arteries in the kidney, and this condition appears to be associated with an increased risk of kidney failure, a multicenter study in China showed. “The presence of renal arteritis may represent a widespread…