Blood Biomarker Able to Quickly Diagnose Active ANCA Vasculitis as Distinct from Infections, Study Reports

A molecule known as chemokine receptor 8 (CCR8) can be seen at significantly high levels in people with active ANCA-associated vasculitis and serve as a blood biomarker of disease activity of importance to treatment, because its serum levels do not alter with infections, a study in Japan reports. Specifically, blood serum…

Eosinophils, a type of immune cell, appear to contribute to the inflammatory process seen in patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), a study shows. The study, “Eosinophils in anti-neutrophil cytoplasmic antibody associated vasculitis,” was published in the journal BMC Rheumatology. ANCA-associated…

A large proportion of patients with ANCA-associated vasculitis (AAV) who develop orbital mass, an eye complication, respond poorly to treatment, a study reports. Future studies need to evaluate the use and effectiveness of combination therapies for the subgroup of patients that are more likely to develop this condition, according…

Patients with ANCA-associated vasculitis producing PR3-ANCA antibodies may have inadequate blood delivery to internal organs, such as the kidneys and spleen, leading to organ malfunction and pain, a case report suggests. The study, “PR3 vasculitis presenting with symptomatic splenic and renal infarction: a case report and…

Testing positive for anti-PR3 antibodies and showing lesions in the lungs and cartilaginous tissues could replace nasal biopsy for diagnosing patients with suspected granulomatosis with polyangiitis (GPA) and chronic rhinosinusitis, according to a pilot study. The study, “Should nasal biopsy inevitably be performed for…

Patients with ANCA-associated vasculitis (AAV) who have persistent antiphospholipid antibodies (APLAs) at diagnosis are at a greater risk of developing blood clots, with consequent obstruction of the blood flow, according to new research. The study, “Persistent antiphospholipid antibodies are associated with thrombotic events in ANCA-associated vasculitis: A retrospective…

High blood levels of a signaling molecule called interleukin-21, or IL-21, may identify patients with active ANCA-associated vasculitis (AVV), a pilot study suggests. The study, “Serum interleukin-21 positivity could indicate the current activity of antineutrophil cytoplasmic antibody-associated vasculitis: a monocentric…

Eye problems are a common symptom of granulomatosis with polyangiitis, of which clinicians should be aware as it can be an initial symptom of the disease, a study reports. Most of the time these manifestations are treatable by conventional immunosuppressive…

In rare cases, people with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis may also have symptoms of a chronic liver disease called primary biliary cirrhosis, a case report shows. To date, only six other cases of these overlapping conditions have been reported in the literature, so researchers have not been able to…

Denosumab, an approved treatment for osteoporosis, may sometimes trigger antineutrophil cytoplasmic antibody (ANCA) associated vasculitis with cytoplasmic ANCAs, a case study reports. While this treatment has been linked with vasculitis, this is the first report of a denosumab-derived cytoplasmic-ANCA vasculitis, the researchers say. The case study, “c-ANCA vasculitis…