Physicians experienced in treating ANCA-associated vasculitis (AAV) generally agree on which disease manifestations are driven by granulomas, or clusters of immune cells, according to a survey study. Such manifestations included masses on the lungs or behind the eye socket, narrowing of the airways below the vocal cords, and…
CD11b, a protein found on the surface of neutrophils — immune cells that are first responders in fighting infections in the body — may be a biomarker of kidney disease in people with ANCA-associated vasculitis (AAV), according to a new study from researchers in China. Levels of activated CD11b on…
Facial palsy, or weakness of the facial muscles, is associated with a nearly 10 times higher risk of hearing loss with granulomatosis with polyangiitis (GPA), a type of ANCA-associated vasculitis (AAV), a single-center study suggests. Older age, along with ear or eye involvement, were also significant risk factors for…
Researchers have identified new contributors to the abnormal immune responses against the myeloperoxidase (MPO) enzyme that drive ANCA-associated vasculitis (AAV) in some patients. Specifically, these abnormal responses are marked by high numbers of memory B-cells that produce an antibody type called immunoglobulin M (IgM). Memory B-cells are immune cells crucial to…
The frequency of ANCA-associated vasculitis (AAV) among the Indigenous peoples of Alaska is high compared with other populations worldwide, especially the granulomatosis with polyangiitis (GPA) form of the disease, Â a study reports. Native Alaskans and American Indians in Alaska with AAV also may have more severe clinical features at…
Among ANCA-associated vasculitis (AAV) patients with kidney failure and waiting for a kidney transplant, undergoing the transplant reduces their risk of dying by more than half relative to continuing on dialysis, a replacement therapy. These findings, from a 20-year study of people in France with AAV listed for a…
Researchers in Japan have identified four distinct subtypes of microscopic polyangiitis, or MPA — a type of ANCA-associated vasculitis (AAV) — that are associated with different clinical characteristics, which may help in better predicting, and improving, patient outcomes, according to the team. One subtype was marked mainly by kidney…
A key sign of heart disease — calcium buildup in the blood vessels that supply the heart, known as coronary artery calcification — was found in a majority of adults with ANCA-associated vasculitis (AAV) in a study by U.S. researchers. Such calcium deposits are associated with atherosclerosis, or the…
Machine learning based on clinicians’ notes found in electronic health records accurately identifies cases of ANCA-associated vasculitis (AAV), a study demonstrated. The model was found to be superior to traditional algorithms based on diagnostic codes with or without medication use at identifying AAV cases. “Its application to EHR [electronic…
A new Phase 3 clinical trial is recruiting children and adolescents with active granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA), the most common types of ANCA-associated vasculitis (AAV), to test Tavneos (avacopan) in combination with rituximab or cyclophosphamide. That’s according to a financial update released by…
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