People with ANCA-associated vasculitis (AAV) who test positive for a staining pattern of self-reactive antibodies called cytoplasmic ANCA (C-ANCAs) are nearly five times more likely to have bleeding into the lungs’ air sacs, known as alveolar hemorrhage, a study found. C-ANCA is marked by the presence of ANCAs —…
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In people with eosinophilic granulomatosis with polyangiitis (EGPA), those with skin or heart involvement have significantly higher blood levels of immunoglobulin E (IgE), a type of natural antibody frequently linked to EGPA, a study showed. Testing positive for the self-reactive antibodies ANCAs against the myeloperoxidase (MPO) protein tended to…
A protein known as NGAL — fully, neutrophil gelatinase-associated lipocalin — appears to be a marker of disease activity and kidney damage severity in people with ANCA-associated vasculitis (AAV) who have kidney inflammation, according to new research by scientists in China. The team found that “in active AAV, [blood]…
Two Phase 1/2 clinical trials testing NKX019 — Nkarta’s cell therapy candidate — are now enrolling participants to test a second, higher dose in people with ANCA-associated vasculitis (AAV) and other autoimmune conditions. The Ntrust-2 study (NCT06733935) is enrolling up to 144 people with AAV, idiopathic inflammatory…
Most people who test positive for ANCAs — the self-reactive antibodies that drive most ANCA-associated vasculitis (AAV) cases — have pauci-immune glomerulonephritis (GN), a type of inflammation of the kidneys’ filtering units, a study found. A high number of blood-clotting-inducing platelets, high blood levels of the inflammatory marker…
Although uncommon, inflammation of the salivary and tear glands can occur in people with ANCA-associated vasculitis (AAV) — most often among those with granulomatosis with polyangiitis (GPA), one of the most common AAV types — according to a new study from researchers in France. The parotid gland, the…
Similar rates of remission and sustained remission were found for people with ANCA-associated vasculitis (AAV) given induction treatment with cyclophosphamide and Tavneos (avacopan) in a clinical trial compared with those receiving cyclophosphamide plus the glucocorticoid prednisone. Still, the Tavneos-based treatment regimen appeared to be associated with a lower…
CD11b, a protein found on the surface of neutrophils — immune cells that are first responders in fighting infections in the body — may be a biomarker of kidney disease in people with ANCA-associated vasculitis (AAV), according to a new study from researchers in China. Levels of activated CD11b on…
People with ANCA-associated vasculitis (AAV) are at a higher risk of developing nonmelanoma skin cancer (NMSC), the most common form of skin cancer, but not other types of cancer, according to a long-term follow-up study in Europe. The use of the immunosuppressive therapy azathioprine, longer azathioprine treatment, and being…
Tavneos (avacopan) can control ANCA-associated vasculitis (AAV) just about as well as standard glucocorticoids but causes fewer side effects — and as such, use of the approved therapy may help people with AAV enjoy a better quality of life. Those are the findings of a review study by…
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