AAV Patients Vary on Preference for Plasma Exchange

Nearly one-third of adults with ANCA-associated vasculitis (AAV) would choose plasma exchange regardless of varying risks of kidney failure and severe infection, according to an international study. One-fifth of patients would make that choice only in high-risk scenarios and one-sixth would reject that treatment in all scenarios, however.

Protein Levels in Blood May Mark AAV Years Before Symptoms Do

The blood levels of several immune-related proteins are significantly altered in people with ANCA-associated vasculitis (AAV) up to five years before they develop symptoms when compared with matched healthy people, a study showed. Changes in these protein levels were found to be involved in inflammatory and metabolic pathways, and…

Rituximab Found Better for GPA Remission Than Cyclophosphamide

Rituximab is superior to cyclophosphamide at inducing disease remission after six months in people with granulomatosis with polyangiitis (GPA) — a type of ANCA-associated vasculitis (AAV) — according to a study in France. Similar findings were found for subgroups of GPA patients, such as those newly diagnosed with the disease…

Top 10 ANCA-Associated Vasculitis Stories of 2022

Over the past year, ANCA Vasculitis News has brought you coverage of the latest developments in research related to ANCA-associated vasculitis (AAV). We look forward to continuing to bring you news about advances in research and treatment in the new year. Here we have compiled a list of the top…

Cyclophosphamide Plus Rituximab Prevents AAV Relapses: Study

Adding a low dose of cyclophosphamide to rituximab for remission induction was safe and more effective at preventing relapses in the first two years in people with severe ANCA-associated vasculitis (AAV) than rituximab alone, a new study shows. No significant benefit was observed in the combination treatment after five years.

Immune Checkpoint Molecules May Serve as Markers of AAV Activity

Blood levels of the soluble forms of CD28 and TIM-3 — two receptor proteins involved in the regulation of immune responses — are significantly associated with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) activity, a study showed. The levels of these so-called immune checkpoint molecules were increased in people with active AAV…

Pausing Immunosuppressants Can Help Clear Hep E Infection in AAV

Hepatitis E infection can be effectively managed in people with ANCA-associated vasculitis (AAV) by pausing immunosuppressive therapy, though patients may experience AAV flares during this pause, a new study shows. “Despite potent immunosuppression before infection, all patients cleared the virus after cessation of the immunosuppressant without additional anti-viral therapy.

1st Case to Report Child With AAV, CNS Symptoms After COVID-19

A 13-year-old girl developed ANCA-associated vasculitis (AAV) with major involvement of the central nervous system after COVID-19, a case study reports. “To our knowledge, this is the first reported pediatric case of ANCA-associated vasculitis with predominant central nervous system involvement after COVID-19 infection,” the researchers wrote. The girl had…