A study linked higher blood levels of tiny sacs carrying immune proteins from the complement system — which is known to contribute to ANCA-associated vasculitis (AAV) — to kidney involvement and damage in AAV patients. The findings could help doctors detect kidney disease in people with AAV and develop…
News
The U.S. Food and Drug Administration (FDA) has cleared the start of clinical testing of FT839, Fate Therapeutics’ experimental off-the-shelf CAR T-cell therapy for ANCA-associated vasculitis (AAV) and other autoimmune disorders. The company plans to launch a basket Phase 1/2 clinical trial to evaluate FT839 in combination with…
Blood cell ratios derived from routine blood tests may help distinguish people with active ANCA-associated vasculitis (AAV) from those in glucocorticoid-free remission, independent of age and sex, according to a new study. “Our findings suggested that these readily available, standardized, low-cost biomarkers make them attractive candidates for integration into…
Black people with ANCA-associated vasculitis (AAV) were diagnosed at a younger age than white people and tended to show more signs of kidney disease severity, according to a study in the U.S. “These findings suggest that [variability] in disease presentation within the spectrum of AAV highlights the importance of examining…
Following regulatory attempts in Europe to revoke approval of its ANCA-associated vasculitis (AAV) therapy Tavneos (avacopan), developer Inflarx is now looking to advance two new treatments — both being tested in clinical trials — for this group of autoimmune diseases. The biopharmaceutical company said in a…
A committee of the European Medicines Agency has recommended revoking the marketing authorization for Tavneos (avacopan) — an approved oral therapy for ANCA-associated vasculitis (AAV) — in the European Union (EU) over questions about the drug’s effectiveness data. The recommendation, from the Committee for Medicinal Products for…
People with eosinophilic granulomatosis with polyangiitis (EGPA) waited a median of nearly four years from their first recorded major sign of the disease to diagnosis, and most received prescriptions for oral glucocorticoids and/or immunosuppressants, a real-world study in England shows. Also, in a 486-patient group followed from diagnosis, more…
Nearly half of ANCA-associated vasculitis (AAV) patients treated with rituximab developed hypogammaglobulinemia (HGG), or low blood levels of antibodies, according to a population-based Swedish study. While antibodies normally help fight infections, the occurrence of HGG was not associated with an increased risk of severe infections among rituximab-treated patients…
The ANCA-associated vasculitis Patient-Reported Outcome (AAV-PRO) questionnaire captures physical, social, emotional, and symptom-related burdens that are closely linked to difficulties in daily life but are not always reflected in physician assessments. That’s according to a study in Germany that used the German-language version of the AAV-PRO questionnaire, which had…
Measuring urine levels of two proteins in people with ANCA-associated vasculitis (AAV) and kidney involvement independently predicted their risk of progression to kidney failure, according to a new study from China. The researchers found that noninvasive testing of trehalase and neutrophil gelatinase-associated lipocalin (NGAL), two highly sensitive urinary biomarkers,…
Recent Posts
- Improving communication with doctors means trusting ourselves as patients
- Nasal, sinus issues in ear, nose, and throat patients may point to AAV
- Teen with AAV among nominees for NKF’s Kidney Hero of the Year
- New resource offers a road map for navigating ANCA-associated vasculitis
- Tracking organ damage after GPA diagnosis predicts relapse risk