News

Permanent organ damage common in ANCA-associated vasculitis

Treatments for ANCA-associated vasculitis (AAV) have improved over time, but many patients still develop permanent organ damage, even though the extent of it has been less severe in recent years, a study in Turkey suggests. Mortality rates have remained largely similar over the years, with death more likely among…

Immunosuppressives aid survival in late ANCA-associated vasculitis

People diagnosed with ANCA-associated vasculitis (AAV) at age 75 or older may show more inflammation, higher rates of kidney involvement, or higher mortality than younger-onset patients based on their AAV type, a study in Japan finds. But immunosuppressive treatment plus standard corticosteroids appears to be more effective than corticosteroids…

Cardiac MRI can detect ANCA-associated vasculitis heart damage

An imaging test that can make detailed pictures of the heart can detect scar tissue buildup in the heart muscle of adults with ANCA-associated vasculitis (AAV), even if they’re not having disease symptoms, a review study shows. “Incorporating cMRI [cardiac MRI] into routine evaluations could improve the detection and…

AAV combo therapy allows for early glucocorticoid withdrawal

Induction therapy with cyclophosphamide and rituximab allows for early discontinuation, without compromising efficacy, of an oral-only glucocorticoid regimen in people with severe ANCA-associated vasculitis (AAV), a study found. Patients on oral glucocorticoids for up to three months showed comparable remission and relapse rates, but tended to have fewer infections…

Immune protein is prognosis sign in ANCA-associated vasculitis

Blood levels of CCL23, an immune molecule that may be involved in blood vessel formation and repair, are significantly increased in people with ANCA-associated vasculitis (AAV) relative to healthy people, a study finds. High blood CCL23 levels accurately differentiate people with active AAV from those in remission and increase…

Awareness Month to focus on personal experiences, connections

Personal stories, community connections, and encouraging videos will be among the highlights as patients, doctors, researchers, and advocates recognize International Vasculitis Day on May 15 and the rest of Vasculitis Awareness Month. Vasculitis is a group of rare autoimmune diseases characterized by inflammation and damage to blood vessels. Most…