Elevated activity of genes of the complement pathway, a part of the immune system, in kidney tissue is associated with impaired kidney function and inflammation in adults with ANCA-associated vasculitis (AAV) and related kidney disease, a study shows. Despite these findings, results from blood tests or tissue staining analysis…
News
Hospitalization rates for ANCA-associated vasculitis (AAV) vary substantially from one country to another, according to a multinational study. Researchers examined hospital records from eight countries, including the U.S., between 2016 and 2022 and found that rates, subtypes, and in-hospital death proportions differed markedly, with Germany and England reporting the…
People with the two most common types of ANCA-associated vasculitis (AAV) face a substantially higher risk of cardiovascular disease and thromboembolism (blood clots) than the general population, according to a nationwide Swedish analysis. The study, which compared over 4,000 patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA)…
One in seven people with ANCA-associated vasculitis (AAV) has renal arteritis, or inflammation of the small arteries in the kidney, and this condition appears to be associated with an increased risk of kidney failure, a multicenter study in China showed. “The presence of renal arteritis may represent a widespread…
Higher levels of the complement protein C5a in urine may provide a noninvasive way of identifying more severe kidney involvement and a greater likelihood of poor outcomes in people with ANCA-associated vasculitis (AAV), a study suggests. In an unadjusted analysis, high urinary C5a was associated with a 3.73-fold higher…
Patient advocates are preparing for the potential withdrawal of Tavneos (avacopan) for ANCA-associated vasculitis (AAV) in the U.K. as regulators there and in the U.S. weigh whether to pull the plug on the therapy’s approval. Authorities in the European Union have…
Fasenra (benralizumab) may provide fast and meaningful benefits for people with severe eosinophilic granulomatosis with polyangiitis (EGPA) who test negative for self-reactive antibodies called ANCAs, according to a small real-world case series. In all three reported cases, AstraZeneca’s treatment resulted in a fast and complete depletion of eosinophils,…
People with ANCA-associated vasculitis (AAV) and severe kidney damage did not see better kidney outcomes with rituximab plus Tavneos (avacopan) than with rituximab alone, a study found. However, the results showed that adding Tavneos to rituximab may help limit the use…
In people with ear, nose, and throat (ENT) symptoms, having nasal crusting, body-wide symptoms, and a poor response to conventional treatments for sinusitis or nosebleeds strongly points to ANCA-associated vasculitis (AAV) as the cause, according to a study. Nasal crusting refers to the buildup of dried mucus and scabs…
A teenage girl who underwent a kidney transplant after experiencing kidney failure associated with ANCA-associated vasculitis (AAV) is among the advocates nominated by the National Kidney Foundation (NKF) for Kidney Hero of the Year. The nominees include individuals, pairs, and families. The new fundraising campaign celebrates advocates…
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