Case of GPA With High Urine Protein Is Unusual

A man with granulomatosis with polyangiitis — a type of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) — and abnormally raised urine protein levels, a sign of kidney disease, has been described in a recent case report. Notably, urine protein levels usually are not significantly elevated in people with granulomatosis…

Lipid Level Increases Could Indicate Cardiovascular Risk in ANCA Vasculitis Subsets, Study Reports

Patients with ANCA-associated vasculitis (AAV) experience significant increases in serum lipid levels during remission induction, particularly those who are newly diagnosed or have anti-PR3 antibodies, according to new research. The findings also indicated that disease phase and antibody type are associated with differential levels of inflammation and could…

Aortic Aneurysm Occurred as Complication of Granulomatosis with Polyangiitis, Case Report Says

Patients with granulomatosis with polyangiitis can rarely develop abdominal aortic aneurysm, a serious condition that can lead to blood vessel rupture and, in extreme circumstances, death. The case report with that finding, “Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case…

Distinct ANCA Autoantibodies Predict Different Organ Involvement, Outcomes in AAV, Study Shows

Classifying the specificity of ANCA autoantibodies may complement the currently used clinical classification system when predicting the course of disease and prognosis in ANCA-associated vasculitis (AAV) patients with renal involvement, according to Spanish researchers. Indeed, ANCA specificity was seen to be better at predicting relapse than clinical classification.