Updates

March 25, 2019
Interleukin-21 Levels May Indicate Disease Activity in AAV Patients, Pilot Study Suggests

High blood levels of a signaling molecule called interleukin-21, or IL-21, may identify patients with active ANCA-associated vasculitis (AVV), a pilot study suggests. ... Read more
March 21, 2019
Eye Problems May Be Early GPA Symptom; Rituxan Helps in Recurrent Cases

Eye problems are a common symptom of granulomatosis with polyangiitis, of which clinicians should be aware as it can be an initial symptom of the ... Read more
March 19, 2019
Case Report Describes Rare Coexistence of Chronic Liver Condition and MPA

In rare cases, people with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis may also have symptoms of a chronic liver disease called primary biliary cirrhosis, a ... Read more
March 18, 2019March 18, 2019
Osteoporosis Treatment Denosumab May Cause ANCA Vasculitis, Case Report Suggests

Denosumab, an approved treatment for osteoporosis, may sometimes trigger antineutrophil cytoplasmic antibody (ANCA) associated vasculitis with cytoplasmic ANCAs, a case study reports. While this ... Read more
March 15, 2019March 14, 2019
Brexit Could Have Real Effects for UK Rare Disease Patients, Experts Warn

Madeline Collin, a 24-year-old activist with Gaucher disease, worries that patients like her will suffer deeply if Britain leaves the European Union (EU), as ... Read more

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News

Small Particles Produced by Platelets May Worsen Inflammation in AAV, Study Contends
March 14, 2019
Platelet-derived microparticles (PMPs) — small particles produced and released by platelets in the blood — may ...
News

Moral Dilemmas Complicate Treatment of Rare Diseases, Says Israeli Bioethicist
March 13, 2019March 11, 2019
With each new advance in medicine comes ethical dilemmas, from fertility treatments and newborn ...
News

Dividing AAV According to Antibodies Provides No Further Benefit for Prognosis, Study Reports
March 12, 2019March 12, 2019
Dividing ANCA-associated vasculitis (AAV) into subgroups defined by type of antibodies does not provide additional ...
News

Rise in MPO-ANCA Antibodies After Remission May Predict Relapse
March 11, 2019
Among ANCA-associated vasculitis patients in remission — particularly those with manifestations in their kidneys ...
News

Antibody Fragment May Be Used to Treat ANCA Vasculitis, Study Reports
March 7, 2019
A piece of an antibody targeting a protein involved in cholesterol transport and metabolism ...
News

NIH Rare Disease Day Highlights Joint Networks Advancing Array of Research
March 6, 2019March 5, 2019
Rare diseases affect about 30 million Americans — roughly the same number as those ...

Low-dose Radiotherapy Could Treat Cancer Caused by GPA Lesions, Case Report Suggests
March 5, 2019
Tumors caused by granulomatosis with polyangiitis (GPA)-related lesions appear to be especially sensitive to radiation ...
MabThera Induction Treatment for AAV Shows Real-world Effectiveness, Study Reports
March 4, 2019
Real-world use of MabThera (rituximab) as an induction treatment for patients with ANCA-associated vasculitis (AAV) on ...
Link Exists Between EGPA and Clotting Disease in Small Blood Vessels, Report Suggests
February 28, 2019
WODC 2019 Organizers Expect 1,200 to Attend Rare Disease Conference in April
February 27, 2019February 25, 2019
Study: IV Methylprednisolone Doesn’t Benefit, May Harm AAV Patients
February 26, 2019
Improved Outcomes in AAV Patients May Be Due to Earlier Diagnosis, Better Management, Study Suggests
February 25, 2019

New Test May Help Determine Disease Activity in GPA Patients, Study Reports
February 21, 2019
A new test measuring the relative abundance of immunoglobulin G4 (IgG4) RNA could be ...
Vienna to Host RARE2019 Meeting on Rare Diseases
February 20, 2019
Patients Testing Positive for ANCA Vasculitis Antibodies May Not Have the Disease, Study Shows
February 19, 2019
Testicular Pain and Swelling Can Be Initial Sign of ANCA-associated Vasculitis, Case Report Finds
February 18, 2019

Reduced Muscle Strength Leads to Poor Quality of Life in ANCA Vasculitis Patients, Study Says
February 14, 2019
Long-term disease and treatment-related damage reduce the muscle strength and physical capacity of people ...
Abnormal Antimicrobial Traps in Lesions May Be Linked to AAV Development, Study Says
February 12, 2019
Lower Doses of Rituxan Equally Effective at Controlling AAV, Study Suggests
February 11, 2019

News

Patients, Family and Friends to Take Part in Variety of Rare Disease Day Events Worldwide
February 11, 2019February 11, 2019
Scores of events are afoot worldwide to mark Feb. 28, Rare Disease Day 2019. The activities ...
News

Radiotherapy Should Be Done Carefully on GPA Patients with Cancer to Avoid Complications, Case Study Suggests
February 7, 2019February 7, 2019
The use of radiation therapy on granulomatosis with polyangiitis (GPA) patients with cancer should be done with ...
News

PredictImmune Granted Patent in Canada for Methods to Predict Autoimmune Disease Progression
February 5, 2019
PredictImmune has expanded its intellectual propriety portfolio with a new patent approved in Canada ...
News

ICD-10 Codes, ‘Really Important’ to Rare Disease Patients, Soon Up for Fresh Consideration
February 5, 2019February 6, 2019
G71.01 is, literally, the code for Duchenne muscular dystrophy. Q93.51 stands for Angelman syndrome, ...
News

Belimumab Maintenance Fails to Delay Relapse in AAV Patients, Phase 3 Trial Suggests
February 4, 2019
A combination of belimumab plus standard maintenance treatment is no better than standard of care alone at ...
News

New Plans Announced for Full Marketing Approval of Avacopan as Treatment for ANCA Vasculitis
January 31, 2019
In light of upcoming Phase 3 data, ChemoCentryx and Vifor Fresenius Medical Care Renal Pharma have ...

January 11, 2018

Early Diagnosis of AAV Symptoms Decreases Risk of Renal Damage, Mortality

News

A retrospective study has found an association between the length of prodromal phase – where patients experience non-specific symptoms before more specific disease signs develop – and mortality in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients. This ... Read more

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