Updates

July 16, 2019
High Blood Pressure and Other Cardiovascular Risks Prevalent in ANCA Vasculitis Patients, Researchers Say

High blood pressure and other cardiovascular risk factors are highly prevalent in people with ANCA-associated vasculitis (AAV), and a sizable number — more ... Read more
July 15, 2019July 15, 2019
Lipid Level Increases Could Indicate Cardiovascular Risk in ANCA Vasculitis Subsets, Study Reports

Patients with ANCA-associated vasculitis (AAV) experience significant increases in serum lipid levels during remission induction, particularly those who are newly diagnosed or have ... Read more
July 11, 2019
Fatigue Persists at High Levels in Some AAV Patients Despite Treatment, Study Shows

People with ANCA-associated vasculitis (AAV) experience much worse fatigue than the general population, and although this eases in many with treatment, a small ... Read more
July 9, 2019
AIMP1 Blood Levels Might Indicate Disease Severity in AAV Patients, Study Reveals

People with ANCA-associated vasculitis who have high levels of a protein called aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1) in their blood serum might be ... Read more
July 8, 2019July 8, 2019
AAV Patients With Low Complement Levels Experience Greater Kidney Damage, Study Reports

Patients with ANCA-associated vasculitis (AAV) with low levels of complement proteins develop greater kidney damage, according to new research. The study, “Increased renal ... Read more

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News

World’s First Alport Stamp Is Macedonian Mom’s Latest Win for Rare Disease Patients
July 4, 2019July 4, 2019
It wasn’t until Gordana Loleska’s son David was 14 years old that doctors in ...
News

Rituxan May Help Treat Aorta Inflammation in AAV, Case Report Suggests
July 2, 2019
In the rare event that ANCA-associated vasculitis affects a large blood vessel like the ...
News

Complement System Plays Role in ANCA-associated Vasculitis, Regardless of ANCA Subtype, Study Says
July 1, 2019July 1, 2019
The complement system, an important part of immunity, is activated in ANCA-associated vasculitis patients ...
News

Major Infections Are Main Cause of Death in AAV Patients, Study Finds
June 27, 2019
Major infections are the main cause of poor long-term outcomes and death in patients ...
News

NORD Honors Industry, Patient Advocates at Rare Impact Awards Gala
June 26, 2019June 25, 2019
A violinist with vasculitis, two Texas politicians and a pharmaceutical company whose marijuana-derived therapy ...
News

AAV Neutrophils Show Increased Activation of the Alternative Complement System, Study Finds
June 25, 2019June 25, 2019
Neutrophils from patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are better at activating ...

Study: Rituxan Reduces Disease Activity in EGPA, But Relapses Stay High
June 24, 2019
Treatment with Rituxan (rituximab) had some efficacy in eosinophilic granulomatosis with polyangiitis patients, leading ...
Eurordis Unveils Integrated-care Initiative for Rare Disease Patients
June 21, 2019June 20, 2019
Europe’s umbrella organization for 800 rare disease associations has developed a sweeping initiative to ...
Rituxan Is Cost-effective for ANCA-associated Vasculitis, Study Says
June 20, 2019
‘Rare Barometer’ Program Helps Eurordis Shape EU Rare Disease Policy
June 19, 2019June 17, 2019
Proteins Linked to Neutrophil Clearance Altered in GPA Patients, Study Finds
June 18, 2019
FDA Grants Priority Review to Rituxan Plus Glucocorticoids for Children with GPA and MPA
June 17, 2019

FDA Approves Autoinjector and Pre-filled Syringe for Self-Administration of Nucala
June 13, 2019June 13, 2019
People who live in the U.S. and have eosinophilic granulomatosis with polyangiitis (EGPA) now ...
High Levels of MPO-ANCA Antibodies Linked to Poor Kidney Function in Long-term, Study Says
June 11, 2019
AAV Patients More Likely to Develop Thyroid Disease, Korean Study Finds
June 6, 2019June 6, 2019
Plasma Exchange Effective for AAV Patients with Severe Renal Damage, Study Reports
June 4, 2019

BVAS and FFS Both Useful Tools for Predicting AAV Prognosis and Choosing Therapy, Study Says
June 3, 2019
The Birmingham Vasculitis Activity Score (BVAS) and the Five Factors Score (FFS) are both ...
Rituxan-Soliris Combo May Replace Glucocorticoids in Treatment of Severe AAV, Case Report Suggests
May 30, 2019May 30, 2019
Blood in Urine Linked to Higher Risk of Kidney Disease Relapse in AAV Patients, Study Finds
May 28, 2019May 28, 2019

News

Agency Unveils RaDaR to Help Patient Groups Develop Rare Disease Registries
May 27, 2019May 24, 2019
RaDaR, the catchy new name for the U.S. government-run Rare Diseases Registry Program, aims ...
News

Urinary Gremlin Protein Levels a Potential Biomarker for ANCA-associated Renal Vasculitis, Study Finds
May 23, 2019
Levels of Gremlin — a protein that is overexpressed during kidney damage — in ...
News

First Patient Dosed in European Trial Testing IFX-1 Investigational Therapy, InflaRx Announces
May 21, 2019
The first patient has been dosed in InflaRx‘s ongoing European Phase 2 clinical trial ...
News

Rare Diseases Constitute a ‘Public Health Issue,’ NCATS Director Warns
May 15, 2019
With 250 rare diseases newly identified every year, scientists can barely keep up — ...
News

ChemoCentryx on Track to Present Topline Data From its Ongoing ADVOCATE Phase 3 Trial on Avacopan
May 14, 2019
ChemoCentryx remains on track to report topline results later this year from its ongoing ...
News

Cerebral Small Vessel Disease Can Be Detected Before Diagnosis of MPO-AAV, Study Suggests
May 9, 2019
In patients with MPO-positive ANCA-associated vasculitis, the excess inflammation causes cerebral small vessel disease ...

January 11, 2018

Early Diagnosis of AAV Symptoms Decreases Risk of Renal Damage, Mortality

News

A retrospective study has found an association between the length of prodromal phase – where patients experience non-specific symptoms before more specific disease signs develop – and mortality in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients. This finding ... Read more

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