Updates

August 22, 2019
Improved Classification Systems Needed for AAV, Study Shows

The autoimmune condition ANCA-associated vasculitis (AAV) needs improved classification systems that can better predict disease outcomes, a Spanish study says. Disease management should ... Read more
August 20, 2019
Intravenous Immunoglobulin Quickly Lowers Disease Activity in AAV Patients, Review Study Finds

Intravenous immunoglobulin (IVIG) therapy leads to a fast and significant reduction in disease activity, as well as in the levels of inflammatory biomarkers, in ... Read more
August 20, 2019August 19, 2019
Nebraska’s Neena Nizar Seeks Cure for Jansen’s, One of World’s Rarest Diseases

Imagine living your whole life with a painful disease so rare that only 25 others worldwide have what you have. And that you’re one ... Read more
August 19, 2019
Immune Cell Profile Classification Useful for Prognosis, Treatment of AAV, Study Finds

Dividing people with active ANCA-associated vasculitis (AAV) into different subgroups may be useful for determining prognosis and selecting each person’s best course ... Read more
August 13, 2019
ANCA Autoantibodies Produced in Healthy People, Study Shows

Healthy individuals also produce a type of self-reactive antibodies — termed IgM ANCA — present in people with ANCA-associated vasculitis (AAV), a study ... Read more

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News

AAV Involving Kidneys May Not Always Start in Glomeruli, Case Report Suggests
August 12, 2019
ANCA-associated vasculitis (AAV) can cause kidney damage without affecting the glomeruli, the filtering unit ...
News

Study Identifies Factors for Renal Recovery for AAV Patients on Dialysis for Kidney Damage
August 8, 2019
Researchers say an important clinical assessment is determining whether ANCA-associated vasculitis patients who need ...
News

Development of Oral Candidiasis Predicts Severe Infections in AAV Patients Receiving Immunosuppressants, Study Shows
August 7, 2019
ANCA-associated vasculitis patients who develop oral candidiasis during treatment with immunosuppressants have a significantly greater ...
News

Treating ANCA Vasculitis in Cancer Patients Best Approach, Case Study Suggests
August 5, 2019
When autoimmune diseases such as ANCA-associated vasculitis are found at the same time as cancer, ...
News

Oklahoma Ranks Lowest on Programs Key to Rare Diseases on NORD’s 2019 State Report Card
August 2, 2019August 1, 2019
Oklahoma suffers more tornadoes than any other state, has the highest per-capita rate of ...
News

Rare Disease Groups Seek Public Support to Renew Newborn Screening Act in Senate
August 1, 2019
Screening newborns for genetic diseases with treatments that can prevent crippling or deadly progression, ...

Levels of Rheumatoid Factor May Mark Two Distinct Types of EGPA, Study Says
August 1, 2019
Levels of rheumatoid factor — an antibody against healthy tissue found in some autoimmune ...
FDA Approves Rituxan Biosimilar Ruxience for 2 ANCA Vasculitis Subtypes
July 30, 2019
The U.S. Food and Drug Administration (FDA) has approved Pfizer‘s Ruxience (rituximab-pvvr), a biosimilar ...
Interleukin-6 Levels Predict Severe Relapses in ANCA Vasculitis Patients on Rituximab, Study Reports
July 29, 2019
Antimicrobial Traps in AAV Patients Differ From Those With SLE, Study Says
July 25, 2019
Alterations in Kidney Cells Could Predict Excess Protein in Urine, Study Suggests
July 23, 2019
Inflammatory Proteins May Serve as Biomarkers of Early Disease, Kidney Damage in AAV, Study Suggests
July 22, 2019

European Initiative Targets Diagnosis, Treatment of Rare Diseases
July 19, 2019July 18, 2019
A new international consortium based in Paris, and funded largely by the 28-member European ...
Fluid Buildup Around Heart Leads to Finding of Vasculitis Subtype EPGA, Case Study Reports
July 18, 2019
High Blood Pressure and Other Cardiovascular Risks Prevalent in ANCA Vasculitis Patients, Researchers Say
July 16, 2019
Lipid Level Increases Could Indicate Cardiovascular Risk in ANCA Vasculitis Subsets, Study Reports
July 15, 2019July 15, 2019

Fatigue Persists at High Levels in Some AAV Patients Despite Treatment, Study Shows
July 11, 2019
People with ANCA-associated vasculitis (AAV) experience much worse fatigue than the general population, and ...
AIMP1 Blood Levels Might Indicate Disease Severity in AAV Patients, Study Reveals
July 9, 2019
AAV Patients With Low Complement Levels Experience Greater Kidney Damage, Study Reports
July 8, 2019July 8, 2019

News

World’s First Alport Stamp Is Macedonian Mom’s Latest Win for Rare Disease Patients
July 4, 2019July 4, 2019
It wasn’t until Gordana Loleska’s son David was 14 years old that doctors in ...
News

Rituxan May Help Treat Aorta Inflammation in AAV, Case Report Suggests
July 2, 2019
In the rare event that ANCA-associated vasculitis affects a large blood vessel like the ...
News

Complement System Plays Role in ANCA-associated Vasculitis, Regardless of ANCA Subtype, Study Says
July 1, 2019July 1, 2019
The complement system, an important part of immunity, is activated in ANCA-associated vasculitis patients ...
News

Major Infections Are Main Cause of Death in AAV Patients, Study Finds
June 27, 2019
Major infections are the main cause of poor long-term outcomes and death in patients ...
News

NORD Honors Industry, Patient Advocates at Rare Impact Awards Gala
June 26, 2019June 25, 2019
A violinist with vasculitis, two Texas politicians and a pharmaceutical company whose marijuana-derived therapy ...
News

AAV Neutrophils Show Increased Activation of the Alternative Complement System, Study Finds
June 25, 2019June 25, 2019
Neutrophils from patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are better at activating ...

January 11, 2018

Early Diagnosis of AAV Symptoms Decreases Risk of Renal Damage, Mortality

News

A retrospective study has found an association between the length of prodromal phase – where patients experience non-specific symptoms before more specific disease signs develop – and mortality in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients. This finding ... Read more

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