Author Archives: Somi Igbene

Complement System Activated Years Before Symptoms in 2 AAV Subtypes

The body’s complement system — comprised of blood proteins that fight infection — is specifically activated in individuals with microscopic polyangiitis and ANCA-associated vasculitis (AAV) with myeloperoxidase (MPO) antibodies years before a patient’s symptoms begin, new research shows. “These findings support differential pathogenic [disease-causing] mechanisms behind” these two AAV…

Progranulin Protein Levels in Blood May Predict AAV Severity

Blood levels of progranulin — a protein involved in cell development, cell growth, and wound healing — may predict the severity of ANCA-associated vasculitis (AAV), a new observational study suggests. According to researchers, serum progranulin, or the protein’s levels in the bloodstream, “could be used as a predictive marker…

Repeat Kidney Biopsies May Help Better Determine Active Disease

After an initial biopsy shows signs of active ANCA-associated vasculitis (AAV) affecting the kidneys, repeat biopsies are better at determining active disease than standard measures of kidney function, a new observational study reports. Such repeat kidney biopsies may help determine treatment response and personalize care plans for people with…