News

In patients with interstitial lung disease, cigarette smoking may sometimes cause the production of ANCA associated antibodies — a hallmark of ANCA-associated vasculitis — without any signs of vessel inflammation, the case of a 57-year-old man suggests. The case report, “Combined pulmonary fibrosis and emphysema with myeloperoxidase-antineutrophil cytoplasmic antibody…

Alterations in the nasal cavity mucosa and throat often are primary symptoms of granulomatosis with polyangiitis (GPA) and it is critical that otolaryngologists are aware of the disease’s head and neck manifestations, researchers say. In a case report, Mayo Clinic researchers highlight some common endoscopic and radiologic findings seen…

Antiviral therapy prevents silent reactivation of cytomegalovirus (CMV) in ANCA-associated vasculitis (AAV) patients and improves patients’ immune responses, a proof-of-concept clinical study shows. These results suggest that antiviral therapy may reduce the risk of infection in these patients. The study, “Subclinical Reactivation of Cytomegalovirus Drives CD4+CD28null T-Cell Expansion…

Patients with ANCA-associated vasculitis who have a kidney condition called glomerulonephritis have higher mortality rates than those without this complication, a study shows. The condition affects 2 in every 100,000 inhabitants, researchers found in a population-based cohort in Minnesota. The study, “Incidence, prevalence, mortality and chronic renal…

A case report of a patient with eosinophilic granulomatosis with polyangiitis (EGPA), with the disease affecting both the heart and lungs, suggests that Rituxan (rituximab) together with corticosteroids might be a successful therapeutic approach. The study, “Eosinophilic Granulomatosis With Polyangiitis and Cardiac Involvement: A Case Report,” appeared in…

Patients with dermatomyositis — a condition marked by muscle weakness and a distinctive skin rash — can develop acute kidney disease due to overlapping autoimmune diseases affecting the small vessels, a case report shows for the first time. The patient described in the report developed both anti-glomerular basement membrane…

Patients with ANCA-associated vasculitis (AAV) with elevated SDMA — a pro-inflammatory molecule — in their blood have a greater risk of kidney failure or death, according to researchers. Their research, “Higher levels of SDMA and not ADMA are associated with poorer survival of trial patients with systemic ANCA-associated…

The ratio of neutrophils to lymphocytes — two types of immune cells — can be used to predict disease activity at diagnosis and risk of relapse in patients with ANCA-associated vasculitis, a new study shows. The study, “Neutrophil to lymphocyte ratio at diagnosis can estimate vasculitis activity and poor…

Roughly 1 in 10 patients with ANCA-associated vasculitis have another overlapping autoimmune disease, such as rheumatoid arthritis, lupus, or scleroderma, according to a study. Patients whose vasculitis is limited to their kidneys appear to be at a greater risk of having an accompanying autoimmune disease, researchers also…

The U.S Food and Drug Administration (FDA) cleared two assays to be used in the diagnosis of ANCA-associated vasculitis (AAV), according to PerkinElmer. Specifically, the FDA cleared the EUROPLUS Granulocyte Mosaic and the EUROIMMUN ANCA IFA — also referred to as EUROIMMUN IFA Granulocyte assays — to be…