Measuring structural features of specialized kidney cells called podocytes could predict short-term proteinuria — excess proteins in urine — in patients with ANCA-associated glomerulonephritis, according to a new study. The research, “Podocytes and Proteinuria in ANCA-Associated Glomerulonephritis: A Case-Control Study,” appeared in the journal Frontiers…
Determining the levels of interleukins in the blood, specifically IL-10 and IL-33, may help identify people with early systemic ANCA-associated vasculitis, and those at risk of kidney damage, a study suggests. The study, “Cytokine profiling in anti neutrophil cytoplasmic antibody-associated vasculitis: a cross-sectional cohort study,” was published…
A new international consortium based in Paris, and funded largely by the 28-member European Union, intends to speed the diagnosis of rare diseases, while also accelerating the development of treatments for the 95% of such illnesses that currently don’t have one. The European Joint Programme on Rare Diseases (EJP…
Cardiac tamponade, the buildup of fluid in the space surrounding the heart, revealed a case of eosinophilic granulomatosis with polyangiitis (EGPA) that was successfully treated with prednisolone and a procedure for removing the fluid, a case report states. The study, “Anti-proteinase 3-positive Eosinophilic Granulomatosis with Polyangiitis Revealed by…
High blood pressure and other cardiovascular risk factors are highly prevalent in people with ANCA-associated vasculitis (AAV), and a sizable number — more than one-third — of patients are not properly treated, researchers report. The work, “Prevalence and management of cardiovascular risk factors in ANCA-associated vasculitis,”…
Patients with ANCA-associated vasculitis (AAV) experience significant increases in serum lipid levels during remission induction, particularly those who are newly diagnosed or have anti-PR3 antibodies, according to new research. The findings also indicated that disease phase and antibody type are associated with differential levels of inflammation and could…
People with ANCA-associated vasculitis (AAV) experience much worse fatigue than the general population, and although this eases in many with treatment, a small subgroup can continue to have high fatigue levels, according to a study in 150 newly diagnosed patients who took part in clinical trials. Those in this…
People with ANCA-associated vasculitis who have high levels of a protein called aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1) in their blood serum might be at higher risk of developing a severe form of the disease, a study has found. The study, “Serum Aminoacyl-tRNA Synthetase-Interacting Multifunctional Protein-1…
Patients with ANCA-associated vasculitis (AAV) with low levels of complement proteins develop greater kidney damage, according to new research. The study, “Increased renal damage in hypocomplementemic patients with ANCA-associated vasculitis: retrospective cohort study,” appeared in the journal Clinical Rheumatology. The complement system — a…
It wasn’t until Gordana Loleska’s son David was 14 years old that doctors in their native North Macedonia diagnosed his kidney, vision, and hearing problems as Alport syndrome. Although she had known for years that something was wrong, the news that David would battle a lifelong rare disease devastated…
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