News

Risk Factors for Acute Exacerbation in ANCA-ILD ID’d in New Study

Poor lung function and high levels of inflammatory biomarkers in the bloodstream were found to be risk factors for acute exacerbation — an episode of sudden symptom worsening — in patients with antineutrophil cytoplasmic antibody (ANCA)-associated interstitial lung disease. That’s according to a new study, “Acute exacerbation…

Switzerland OK’s Tavneos as Add-on Therapy for GPA, MPA

Tavneos (avacopan) has been approved as an add-on therapy for adults in Switzerland with severe, active microscopic polyangiitis (MPA) or granulomatosis polyangiitis (GPA), the two main types of ANCA-associated vasculitis (AAV). Following the decision by the Swiss Agency for Therapeutic Products, Swissmedic, the launch of Tavneos is expected…

Increased Arterial Stiffness Seen in Patients in Long-term Remission

People with ANCA vasculitis (AAV) in long-term remission have increased arterial stiffness, a sign of cardiovascular disease, a study reports. The mechanisms underlying acute cardiovascular disease risk in AAV were associated with endothelin-1, a molecule that promotes blood vessel narrowing. In the placebo-controlled study, blocking endothelin-1 receptors was found…

Pro-inflammatory S100 Proteins Found to Play Role in AAV

Elevated levels of certain pro-inflammatory proteins were found in the bloodstream and urine of people with ANCA-associated vasculitis (AAV), and correlated with disease severity, a study shows. Findings suggest that two of these proteins — S100A8/A9 and S100A12 — from the S100 family of proteins, play a role in…

Altered Blood Vessel Repair Process ID’d in GPA Remission Patients

The function of endothelial colony-forming cells (ECFCs) is impaired in people with granulomatosis with polyangiitis (GPA) — a type of ANCA-associated vasculitis (AAV) — who are in disease remission, according to a recent study. Impairments in ECFCs’ ability to repair damaged blood vessels — their normal role — even…

Immune Checkpoint Molecules Linked to Risk of Relapse in AAV

Blood levels of molecules called soluble immune checkpoints (sICPs) may serve as biomarkers of relapse risk in people with ANCA-associated vasculitis (AAV), a study found. Patients with lower levels of these molecules were more likely to relapse after being in remission following treatment with rituximab, but were less likely…

Eye, Ear Symptoms Common in AAV Patients With Rare Condition

Symptoms affecting the eyes and ears are significantly more common in adults with ANCA-associated vasculitis (AAV) who developed hypertrophic pachymeningitis (HP), a rare condition marked by brain inflammation, a study from Japan reported. Notably, sudden vision or hearing loss was found in AAV patients with HP, suggesting that eye…