High blood creatinine levels and results from kidney biopsies at the time of diagnosis were the best predictors of kidney failure risk in people with ANCA-associated vasculitis (AAV) with severe kidney disease, a study found. Blood creatinine levels, a marker of kidney damage, and kidney biopsy findings also predicted…
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ANCA-associated vasculitis (AAV) patients receiving a cumulative dose of at least 935 mg of glucocorticoids over six months are more likely to see clinically meaningful side effects, according to a study using calculations based on the Glucocorticoid Toxicity Index (GTI). The findings suggest the GTI, which considers the frequency…
Recruitment is continuing in three countries for a Phase 1b/2a clinical trial testing Alpine Immune Sciences’ povetacicept in adults with autoimmune conditions affecting the kidneys, including ANCA-associated vasculitis (AAV). Called RUBY-3 (NCT05732402), the early study is designed to enroll an estimated 56 patients, ages 18 and older,…
Two blood parameters — interleukin 8 (IL-8) and the neutrophil/lymphocyte ratio (NLR) — may help identify ANCA-associated vasculitis (AAV) patients with high disease activity and those at risk of poor prognosis, a single center study in China suggests. “IL-18 may be adopted as one of the important biological markers…
The Renal Risk Score may be a better histopathologic classification model than Berden for predicting long-term loss of kidney function in people with ANCA-related vasculitis (AAV) who have glomerulonephritis, an inflammation of the kidneys’ filtering units, a study finds. Incorporating the renal risk score into clinical decision-making could help…
The Kidney Disease: Improving Global Outcomes (KDIGO) work group has released an updated practice guideline based on developments in how best to manage ANCA-associated vasculitis (AAV) associated with inflammation or damage to the kidneys. The guideline now offers advice on the use of lower doses of…
Biomarkers measured in blood or urine may help track disease activity and organ damage in people with ANCA-associated vasculitis (AAV), according to a systematic review study. AAV is an autoimmune disorder in which self-reactive antibodies called anti-neutrophil cytoplasmic antibodies (ANCAs) attack the body’s own neutrophils — a type of…
Fasenra (benralizumab), which is approved for a rare type of asthma, and Nucala (mepolizumab) were similarly effective at inducing remission in eosinophilic granulomatosis with polyangiitis (EGPA), but more people on Fasenra were able to stop using oral corticosteroids (OCS), with fewer monthly injections. That’s according to final published…
Occupational exposure to silica, one of the most common minerals in the earth’s crust, may lead to microscopic polyangiitis (MPA) — a type of ANCA-associated vasculitis — particularly in individuals with a genetic predisposition to autoimmune diseases, a case report suggests. Silica, found in sand and rocks, is known to…
ANCA-associated vasculitis (AAV) relapses occur more frequently during the summer and spring, particularly for people with granulomatosis with polyangiitis (GPA) or with anti-proteinase 3 (PR3) antibodies, a study in Japan reports. More frequent nasal infections caused by the bacterium Staphylococcus aureus during the summer in Japan may trigger inflammation…
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