Steve Bryson, PhD, science writer —

Steve holds a PhD in biochemistry from the Faculty of Medicine at the University of Toronto, Canada. As a medical scientist for 18 years, he worked in both academia and industry, where his research focused on the discovery of new vaccines and medicines to treat inflammatory disorders and infectious diseases. Steve is a published author in multiple peer-reviewed scientific journals and a patented inventor.

Articles by Steve Bryson

Switzerland OK’s Tavneos as Add-on Therapy for GPA, MPA

Tavneos (avacopan) has been approved as an add-on therapy for adults in Switzerland with severe, active microscopic polyangiitis (MPA) or granulomatosis polyangiitis (GPA), the two main types of ANCA-associated vasculitis (AAV). Following the decision by the Swiss Agency for Therapeutic Products, Swissmedic, the launch of Tavneos is expected…

Increased Arterial Stiffness Seen in Patients in Long-term Remission

People with ANCA vasculitis (AAV) in long-term remission have increased arterial stiffness, a sign of cardiovascular disease, a study reports. The mechanisms underlying acute cardiovascular disease risk in AAV were associated with endothelin-1, a molecule that promotes blood vessel narrowing. In the placebo-controlled study, blocking endothelin-1 receptors was found…

Pro-inflammatory S100 Proteins Found to Play Role in AAV

Elevated levels of certain pro-inflammatory proteins were found in the bloodstream and urine of people with ANCA-associated vasculitis (AAV), and correlated with disease severity, a study shows. Findings suggest that two of these proteins — S100A8/A9 and S100A12 — from the S100 family of proteins, play a role in…

Eye, Ear Symptoms Common in AAV Patients With Rare Condition

Symptoms affecting the eyes and ears are significantly more common in adults with ANCA-associated vasculitis (AAV) who developed hypertrophic pachymeningitis (HP), a rare condition marked by brain inflammation, a study from Japan reported. Notably, sudden vision or hearing loss was found in AAV patients with HP, suggesting that eye…

AAV-caused Kidney Involvement Is Linked to Immune Monocyte Cells

Similar to neutrophils, immune monocyte cells play an essential role in kidney damage caused by ANCA-associated vasculitis (AAV), a study discovered. The pro-inflammatory function of monocytes was stimulated by the immune signaling protein CSF2, also called GM-CSF. Therapeutically targeting monocytes or CSF2 may be a potential new treatment strategy…

Subtype of B-cells Linked to Kidney Disease in AAV, Study Discovers

A subtype of antibody-producing B-cells was significantly higher in the bloodstream of ANCA-associated vasculitis (AAV) patients with active kidney involvement compared with those who were in remission and healthy individuals. These findings may help monitor disease progression, as well as provide insights into AAV development, the researchers noted. The…

Inflammatory Protein, PTX3, May Be Potential AAV Diagnostic Biomarker

Significantly high levels of the inflammatory protein pentraxin-3 (PTX3) were found in the bloodstream and urine of people with ANCA-associated vasculitis (AAV), particularly those with kidney involvement, a study revealed. Unlike C-reactive protein (CRP), a widely used inflammatory biomarker, PTX3 correlated with standard measures of AAV disease activity before…

Cardiovascular Disease Risk Likely Increases After AAV Diagnosis

People with ANCA-associated vasculitis (AAV) have a higher risk of cardiovascular disease, especially in the months immediately following AAV diagnosis, a population-based analysis found. “Our study demonstrates a key ‘high-risk window’ that should prompt careful monitoring for CV [cardiovascular] disease and aggressive risk factor reduction,” the scientists said. The…