Nearly one in 10 ANCA-associated vasculitis (AAV) patients receiving azathioprine as a maintenance treatment for their condition develop hypersensitivity to the therapy, which manifests as whole body inflammation and skin eruptions, increasing the risk of relapse. Researchers should be aware of this complication, which is more common than previously thought, to…
Levels of calprotectin in the blood correlate with markers of disease activity and a worsening in kidney function in ANCA-associated vasculitis patients, researchers in Spain report. The study, “Calprotectin as a smoldering activity detection tool and renal prognosis biomarker in ANCA associated vasculitis,” was published in the journal…
Patients with ANCA-associated vasculitis (AAV) who receive a minimal glucocorticoid treatment along with Rituxan (rituximab) and cyclophosphamide show similar improvement as those given standard glucocorticoid regimens, but have lower glucocorticoid-associated adverse events, a study shows. The study, “A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody–associated vasculitis,” was published…
Most patients with eosinophilic granulomatosis with polyangiitis (EGPA) test positive for anti-neutrophil cytoplasmic autoantibodies (ANCAs) in sputum samples, even if they show no signs of them in their blood, researchers from Canada and the United States found. These patients have more severe lung involvement, the study shows, suggesting that measuring…
Patients with ANCA-associated vasculitis (AAV) who have renal symptoms might benefit from a kidney biopsy along with measurements of ANCA antibodies and kidney function to predict their renal outcomes, a Chinese study reported. The study, “An evaluation of the 2010 histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis: a…
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