News

People with ANCA-associated vasculitis (AAV) have an 83% higher risk of developing cardiovascular and cerebrovascular diseases (CCVD) relative to those without vasculitis, according to a review study that also showed the risk was significantly higher in the first two years after an AAV diagnosis. “These findings underline the importance…

Conduit Pharmaceuticals is planning to launch Phase 2a clinical trials to test its lead oral candidate AZD1656 in people with immune system disorders — specifically ANCA-associated vasculitis (AAV) as one indication. “With its potential to become a first-in-class therapy for autoimmune diseases, AZD1656 represents a significant leap forward…

Blood tests that look for the anti-neutrophil cytoplasmic autoantibodies (ANCAs) that cause ANCA-associated vasculitis (AAV) may help identify patients with kidney involvement, a study shows. Still, ANCA testing was not as accurate for this purpose as a kidney biopsy, wherein a small piece of kidney tissue is collected…

Researchers have identified a set of clinical red flags that could help detect eosinophilic granulomatosis with polyangiitis (EGPA), the rarest type of ANCA-associated vasculitis (AAV). Among the red flags are specific high-level thresholds of eosinophils, a type of immune cell, combined with other signs including asthma, nasal polyps,…

About 1 in 10 people with idiopathic interstitial pneumonia (IIP), a condition marked by lung scarring of an unknown cause, who test positive for antineutrophil cytoplasmic antibodies, or ANCAs, eventually develop ANCA-associated vasculitis (AAV), a study shows. These patients’ risk factors for AAV include testing positive for ANCAs against…

NorthStar Medical Radioisotopes will sponsor an investigator-initiated research program focusing on the use of radioisotopes in diagnosing and treating ANCA-associated vasculitis (AAV), among other program goals. A radioisotope, or radioactive isotope, is an unstable form of a chemical element that releases radiation to return to a more stable…

Eye symptoms related to ANCA-associated vasculitis (AAV) are most common among those with granulomatosis with polyangiitis (GPA), affecting more than one-third of these patients, a new study from China showed. “These insights collectively underscore the importance of consistent ocular [eye-related] assessments for AAV patients, enabling the monitoring of disease…

Adding Tavneos (avacopan) to standard maintenance treatment safely and effectively promotes disease remission in ANCA-associated vasculitis (AAV) patients, according to a real-world study involving five German centers. In fact, remission rates after one year of Tavneos treatment were higher than those reported in the Phase 3 ADVOCATE…

Using benralizumab — a medication approved in the U.S. for a rare type of asthma — off-label as an add-on to standard induction treatment resulted in a high rate of disease remission in people with eosinophilic granulomatosis with polyangiitis (EGPA) and severe asthma. That’s according to a real-world study in…

The production of new B-cells, a type of immune cell that helps fight infections but is also involved in the abnormal immune attacks that drive ANCA-associated vasculitis (AAV), is dysfunctional in people with the autoimmune disease, a study found. The findings could help shed light on the biological underpinnings…