News

A Phase 1 clinical trial assessing SC291, an experimental CAR T-cell therapy that Sana Biotechnology is developing for ANCA-associated vasculitis (AAV) and other autoimmune diseases, is recruiting patients at a number of sites across the U.S. Called GLEAM (NCT06294236), the study started enrolling up to…

A higher risk of death among AAV patients with interstitial lung disease (ILD) is significantly associated with older age, episodes of sudden symptom worsening, and microscopic polyangiitis (MPA), a common type of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV). That’s according to a review of published studies that also pointed…

Researchers have identified new contributors to the abnormal immune responses against the myeloperoxidase (MPO) enzyme that drive ANCA-associated vasculitis (AAV) in some patients. Specifically, these abnormal responses are marked by high numbers of memory B-cells that produce an antibody type called immunoglobulin M (IgM). Memory B-cells are immune cells crucial to…

The frequency of ANCA-associated vasculitis (AAV) among the Indigenous peoples of Alaska is high compared with other populations worldwide, especially the granulomatosis with polyangiitis (GPA) form of the disease,  a study reports. Native Alaskans and American Indians in Alaska with AAV also may have more severe clinical features at…

Lower blood levels of glutathione peroxidase-3 (GPX-3), an antioxidant enzyme, are significantly associated with greater disease activity and blood vessel damage in people with ANCA-associated vasculitis (AAV), a study found. “We demonstrated that [blood] GPX-3 concentration at diagnosis has the potential to be a novel biomarker that can assess…

Long-term treatment with Nucala (mepolizumab) reduces disease activity and helps to prevent progressive organ damage in people with eosinophilic granulomatosis with polyangiitis (EGPA), the rarest type of ANCA-associated vasculitis (AAV), data from a real-world study show. Finding among patients in Spain also showed that most using Nucala were able…

Among ANCA-associated vasculitis (AAV) patients with kidney failure and waiting for a kidney transplant, undergoing the transplant reduces their risk of dying by more than half relative to continuing on dialysis, a replacement therapy. These findings, from a 20-year study of people in France with AAV listed for a…

Researchers in Japan have identified four distinct subtypes of microscopic polyangiitis, or MPA — a type of ANCA-associated vasculitis (AAV) — that are associated with different clinical characteristics, which may help in better predicting, and improving, patient outcomes, according to the team. One subtype was marked mainly by kidney…

People with ANCA-associated vasculitis (AAV) patients whoo have low blood levels of sulfatides, a type of fatty molecule, are significantly more likely to have future kidney failure, a single-center study in South Korea indicates. The predictive potential of blood sulfatide levels was independent of direct associations with kidney involvement…

A key sign of heart disease — calcium buildup in the blood vessels that supply the heart, known as coronary artery calcification — was found in a majority of adults with ANCA-associated vasculitis (AAV) in a study by U.S. researchers. Such calcium deposits are associated with atherosclerosis, or the…