Updated criteria for classifying ANCA-associated vasculitis (AAV) in adults better discriminate between the AAV types granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) in children than the current pediatric classification criteria. That’s according to a study comparing classification results of 574 children between the…
News
Treatment with Nkarta’s lead candidate NKX019 in two ongoing, early-phase clinical trials may soon be available in outpatient settings — potentially expanding access for people with ANCA-associated vasculitis (AAV) and other autoimmune disorders — thanks to a new regulatory nod. The company announced it has reached an agreement…
The time it takes to diagnose ANCA-associated vasculitis (AAV) may be influenced by disease type, organ involvement, and the medical specialties consulted, according to a single-center study in Germany. The longest median time to diagnosis was seen in people with eosinophilic granulomatosis with polyangiitis (EGPA), the rarest type…
Although long-term survival for people with eosinophilic granulomatosis with polyangiitis (EGPA) has improved in Japan, the introduction of Nucala (mepolizumab) as a treatment for the disease may not, on its own, have had a significant effect. That’s according to a real-world study that analyzed data from 87 EGPA…
A new prediction tool may help identify which people with ANCA-associated vasculitis (AAV) are at risk of developing venous thromboembolism (VTE), a condition in which blood clots block blood flow through veins, a study showed. Using real-world patient data, researchers developed the AAV-VTE model based on four factors that…
ANCA-associated vasculitis (AAV), marked by inflammation and damage to small blood vessels in the body, still shows low-level immune activity in the background even when symptoms are absent, a study found. This is particularly true for its rare type EGPA, fully, eosinophilic granulomatosis with polyangiitis, according to the…
ANCA-associated vasculitis (AAV) patients with kidney failure requiring long-term dialysis have survival rates comparable to those of people with kidney failure due to other causes, according to a registry-based study in China. Among the 54 AAV patients identified in the dialysis registry, death was mainly due to infections, and none…
Nkarta said it expects initial data from a clinical trial testing its cell therapy candidate NKX019 in adults with ANCA-associated vasculitis (AAV) and other autoimmune diseases to be presented later this year. The Phase 1/2 Ntrust-2 trial (NCT06733935) is testing several doses of NKX019 in up to…
People with ANCA-associated vasculitis (AAV) are more likely to have worse kidney function and related outcomes if their self-targeting antibodies, called ANCAs, activate immune cells via the Fc gamma receptor protein, a study suggested. “[Fc gamma-driven] ANCA can be a biomarker for poor kidney prognosis in ANCA-associated vasculitis,” the…
Adding plasma exchange, a blood-cleaning procedure, to standard therapy to induce disease remission may help reduce short-term mortality in people with ANCA-associated vasculitis (AAV) with poor kidney function, a study in China shows. Still, mortality rates at one year were comparable between patients who received plasma exchange and those…
Recent Posts
- Current adult AAV criteria better at classifying the disease in children
- Nkarta cell therapy trial may soon offer outpatient treatment option in AAV
- The importance of rest in managing vasculitis-related fatigue
- Diagnostic delays in AAV vary by subtype and disease features
- EGPA long-term survival rates improving for many reasons: Study