News

Higher levels of the complement protein C5a in urine may provide a noninvasive way of identifying more severe kidney involvement and a greater likelihood of poor outcomes in people with ANCA-associated vasculitis (AAV), a study suggests. In an unadjusted analysis, high urinary C5a was associated with a 3.73-fold higher…

Patient advocates are preparing for the potential withdrawal of  Tavneos (avacopan) for ANCA-associated vasculitis (AAV) in the U.K. as regulators there and in the U.S. weigh whether to pull the plug on the therapy’s approval. Authorities in the European Union have…

Fasenra (benralizumab) may provide fast and meaningful benefits for people with severe eosinophilic granulomatosis with polyangiitis (EGPA) who test negative for self-reactive antibodies called ANCAs, according to a small real-world case series. In all three reported cases, AstraZeneca’s treatment resulted in a fast and complete depletion of eosinophils,…

People with ANCA-associated vasculitis (AAV) and severe kidney damage did not see better kidney outcomes with rituximab plus Tavneos (avacopan) than with rituximab alone, a study found. However, the results showed that adding Tavneos to rituximab may help limit the use…

In people with ear, nose, and throat (ENT) symptoms, having nasal crusting, body-wide symptoms, and a poor response to conventional treatments for sinusitis or nosebleeds strongly points to ANCA-associated vasculitis (AAV) as the cause, according to a study. Nasal crusting refers to the buildup of dried mucus and scabs…

A teenage girl who underwent a kidney transplant after experiencing kidney failure associated with ANCA-associated vasculitis (AAV) is among the advocates nominated by the National Kidney Foundation (NKF) for Kidney Hero of the Year. The nominees include individuals, pairs, and families. The new fundraising campaign celebrates advocates…

Tracking organ damage over the first year after a diagnosis of granulomatosis with polyangiitis (GPA), the most common type of ANCA-associated vasculitis (AAV), predicts relapse risk more reliably than a single damage measurement early in the disease course, a study found. GPA patients whose cumulative damage score reached a…

A new study from Japan found that people with ANCA-associated vasculitis (AAV) have significantly higher levels of a protein known as AIM, fully apoptosis inhibitor of macrophage, in their urine than individuals without this vasculitis type — and these levels may be a useful way to monitor an individual’s…

Six-month remission rates with biosimilar versions of rituximab were similar to those seen with the original therapy among adults with the two most common types of ANCA-associated vasculitis (AAV), according to a real-world study in Canada. Data also showed no significant differences in serious adverse events or AAV-related…

The presence of clumps of inflammatory cells, or granulomas, in the liver is a rare manifestation of ANCA-associated vasculitis (AAV) that varies widely and can be difficult to diagnose, according to the findings of a new study from Tunisia. While liver problems are common in AAV, the researchers noted…