Children with ANCA-associated vasculitis (AAV) often have more active inflammation of the kidneys, as well as more severe signs of kidney disease, than do adults with AAV, according to a new study from France and Italy. Still, with monitoring and treatment, the long-term outcomes for pediatric patients are similar…
News
Following allegations of manipulated data in its regulatory application, a division of the U.S. Food and Drug Administration (FDA) has proposed withdrawing Tavneos (avacopan), an oral treatment approved for the most common forms of ANCA-associated vasculitis (AAV), from the market. In a press announcement, the FDA’s Center…
Blood levels of transferrin (Tf), a protein that transports iron in the body, may serve as a useful biomarker for tracking the activity, treatment response, and outcomes of ANCA-associated vasculitis (AAV). That’s according to a new study by researchers in China that found that individuals with active AAV had…
Updated criteria for classifying ANCA-associated vasculitis (AAV) in adults better discriminate between the AAV types granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) in children than the current pediatric classification criteria. That’s according to a study comparing classification results of 574 children between the…
Treatment with Nkarta’s lead candidate NKX019 in two ongoing, early-phase clinical trials may soon be available in outpatient settings — potentially expanding access for people with ANCA-associated vasculitis (AAV) and other autoimmune disorders — thanks to a new regulatory nod. The company announced it has reached an agreement…
The time it takes to diagnose ANCA-associated vasculitis (AAV) may be influenced by disease type, organ involvement, and the medical specialties consulted, according to a single-center study in Germany. The longest median time to diagnosis was seen in people with eosinophilic granulomatosis with polyangiitis (EGPA), the rarest type…
Although long-term survival for people with eosinophilic granulomatosis with polyangiitis (EGPA) has improved in Japan, the introduction of Nucala (mepolizumab) as a treatment for the disease may not, on its own, have had a significant effect. That’s according to a real-world study that analyzed data from 87 EGPA…
A new prediction tool may help identify which people with ANCA-associated vasculitis (AAV) are at risk of developing venous thromboembolism (VTE), a condition in which blood clots block blood flow through veins, a study showed. Using real-world patient data, researchers developed the AAV-VTE model based on four factors that…
ANCA-associated vasculitis (AAV), marked by inflammation and damage to small blood vessels in the body, still shows low-level immune activity in the background even when symptoms are absent, a study found. This is particularly true for its rare type EGPA, fully, eosinophilic granulomatosis with polyangiitis, according to the…
ANCA-associated vasculitis (AAV) patients with kidney failure requiring long-term dialysis have survival rates comparable to those of people with kidney failure due to other causes, according to a registry-based study in China. Among the 54 AAV patients identified in the dialysis registry, death was mainly due to infections, and none…
Recent Posts
- Kidney inflammation often worse for children with AAV vs. adults, study finds
- Using the spoon theory to manage my energy with chronic illness
- FDA proposes removing Tavneos from market over data concerns
- Testing iron protein in blood may improve AAV monitoring and care
- Even with ANCA vasculitis, we can be awe-struck by our own bodies