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A new prediction tool may help identify which people with ANCA-associated vasculitis (AAV) are at risk of developing venous thromboembolism (VTE), a condition in which blood clots block blood flow through veins, a study showed. Using real-world patient data, researchers developed the AAV-VTE model based on four factors that…

ANCA-associated vasculitis (AAV), marked by inflammation and damage to small blood vessels in the body, still shows low-level immune activity in the background even when symptoms are absent, a study found. This is particularly true for its rare type EGPA, fully, eosinophilic granulomatosis with polyangiitis, according to the…

ANCA-associated vasculitis (AAV) patients with kidney failure requiring long-term dialysis have survival rates comparable to those of people with kidney failure due to other causes, according to a registry-based study in China. Among the 54 AAV patients identified in the dialysis registry, death was mainly due to infections, and none…

Nkarta said it expects initial data from a clinical trial testing its cell therapy candidate NKX019 in adults with ANCA-associated vasculitis (AAV) and other autoimmune diseases to be presented later this year. The Phase 1/2 Ntrust-2 trial (NCT06733935) is testing several doses of NKX019 in up to…

People with ANCA-associated vasculitis (AAV) are more likely to have worse kidney function and related outcomes if their self-targeting antibodies, called ANCAs, activate immune cells via the Fc gamma receptor protein, a study suggested. “[Fc gamma-driven] ANCA can be a biomarker for poor kidney prognosis in ANCA-associated vasculitis,” the…

Adding plasma exchange, a blood-cleaning procedure, to standard therapy to induce disease remission may help reduce short-term mortality in people with ANCA-associated vasculitis (AAV) with poor kidney function, a study in China shows. Still, mortality rates at one year were comparable between patients who received plasma exchange and those…

In most people with kidney damage due to ANCA-associated vasculitis (AAV), outcomes from initial treatment to bring the disease under control are similar across commonly used immunosuppressive therapies, including cyclophosphamide and rituximab. That’s according to a study analyzing data from hundreds of patients at several European centers.

People with ANCA-associated vasculitis (AAV) who develop bronchiectasis — a chronic lung condition marked by permanent widening of certain parts of the airways — may face a higher risk of serious infections and death, according to a new study. The researchers found that bronchiectasis in individuals with granulomatosis with polyangiitis…

A risk score that combines blood tests and kidney biopsy findings performed among the strongest tools for predicting kidney failure in people with ANCA-associated vasculitis (AAV), a small study suggests. The analysis also showed that all three risk scoring systems evaluated remained linked to the risk of kidney failure…

At diagnosis, half of adults with ANCA-associated vasculitis (AAV) already have signs of interstitial lung disease (ILD), a condition marked by inflammation and progressive scarring of lung tissue, according to a new single-center study in Italy. Evidence of lung disease was particularly prevalent among those with microscopic polyangiitis (MPA),…