News

Nearly half of ANCA-associated vasculitis (AAV) patients treated with rituximab developed hypogammaglobulinemia (HGG), or low blood levels of antibodies, according to a population-based Swedish study. While antibodies normally help fight infections, the occurrence of HGG was not associated with an increased risk of severe infections among rituximab-treated patients…

The ANCA-associated vasculitis Patient-Reported Outcome (AAV-PRO) questionnaire captures physical, social, emotional, and symptom-related burdens that are closely linked to difficulties in daily life but are not always reflected in physician assessments. That’s according to a study in Germany that used the German-language version of the AAV-PRO questionnaire, which had…

Measuring urine levels of two proteins in people with ANCA-associated vasculitis (AAV) and kidney involvement independently predicted their risk of progression to kidney failure, according to a new study from China. The researchers found that noninvasive testing of trehalase and neutrophil gelatinase-associated lipocalin (NGAL), two highly sensitive urinary biomarkers,…

Certain T-cells may show excessive activity in a signaling pathway called STAT3-PIM1 in people with granulomatosis with polyangiitis (GPA) who test positive for antibodies against proteinase 3 (PR3-GPA), according to a new study. Researchers aimed to identify unique activity patterns in T-cells containing the CD4 protein marker (CD4+ T-cells),…

Long-term treatment with Nucala (mepolizumab) was linked to systemic disease remission in more than 90% of people with eosinophilic granulomatosis with polyangiitis (EGPA) in a real-world study in Italy, but sinonasal disease often persisted. Sinonasal manifestations affect the nasal cavity and the paranasal sinuses, the air-filled spaces within…

Older adults with ANCA-associated vasculitis (AAV) may achieve more favorable outcomes when induction therapy — an often intensive treatment approach aimed at quickly bringing active disease under control — is tailored to frailty and disease severity, a study suggests. Among adults ages 75 and older with severe active AAV…

Hispanic children and adolescents with ANCA-associated vasculitis (AAV) are significantly more likely to have severe disease and to develop kidney failure than their white counterparts, according to a study in the U.S. Other predictors of severe AAV and kidney failure included the AAV type microscopic polyangiitis (MPA) and…

Among people with ANCA-associated vasculitis (AAV) and interstitial lung disease (ILD), severe lung scarring and poorer lung function at the time of ILD diagnosis are tied to a higher risk of lung disease progression, respiratory failure, and death, a European study shows. ILD is a condition marked by inflammation and progressive…

In people with ANCA-associated vasculitis (AAV), infections were associated with higher odds of relapse and cardiovascular events, as well as a higher risk of death over time, according to a study in France. Data also showed that testing positive for self-reactive antibodies against the proteinase 3 (PR3) protein was…

Lung damage in people with ANCA-associated vasculitis (AAV) can vary widely depending on the type of self-reactive antibodies driving the disease. That’s according to the findings of a new study of AAV patients in Japan that used images from cast high-resolution CT scans, known as HRCTs. Specifically, the data…