Blocking Immune Molecule IL-21 May Be Target as MPO-AAV Therapy

Blocking Immune Molecule IL-21 May Be Target as MPO-AAV Therapy

Levels of the immune signaling molecule interleukin-21 (IL-21) and the cells that produce the protein were elevated in the blood of people with ANCA-associated vasculitis (AAV) with myeloperoxidase (MPO) antibodies, a study found. IL-21 levels also were linked to higher MPO levels and disease activity, suggesting its direct involvement in…

Celebrating 1 Year of Writing This Column

I began this column for ANCA Vasculitis News one year ago this month. It’s been such a joy interacting with other patients who read and connect with my words. At first, the concept of writing once weekly seemed intimidating. How would I come up with a new topic every…

AAV Emerges in Boy Using Levamisole to Treat Kidney Disease

ANCA-associated vasculitis (AAV) emerged as a side effect of levamisole given for years to treat a 15-year-old boy with idiopathic nephrotic syndrome, according to a case report. “By reporting this case, we want to raise awareness among clinicians regarding a rare complication of treatment with Levamisole that is often…