News

ANCA-associated vasculitis (AAV) emerged as a side effect of levamisole given for years to treat a 15-year-old boy with idiopathic nephrotic syndrome, according to a case report. “By reporting this case, we want to raise awareness among clinicians regarding a rare complication of treatment with Levamisole that is often…

A 65-year-old man developed granulomatosis with polyangiitis (GPA), a type of anti-neutrophilic cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV), after receiving a stem cell transplant for another autoimmune condition, according to a case report. “[Our] case report suggests that [AAV] may develop in the setting of stem cell transplantation and must…

People with eosinophilic granulomatosis with polyangiitis (EGPA) are more likely to report a greater range of symptoms than their doctors, a study that drew on patient- and physician-reported databases found, while showing similarities on other points, like relapse frequency. Given the importance of the patient perspective in both research and…

A man with granulomatosis with polyangiitis — a type of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) — and abnormally raised urine protein levels, a sign of kidney disease, has been described in a recent case report. Notably, urine protein levels usually are not significantly elevated in people with granulomatosis…

A subtype of antibody-producing B-cells was significantly higher in the bloodstream of ANCA-associated vasculitis (AAV) patients with active kidney involvement compared with those who were in remission and healthy individuals. These findings may help monitor disease progression, as well as provide insights into AAV development, the researchers noted. The…

Many ANCA-associated vasculitis (AAV) patients with skin lesions test negative for ANCA antibodies — proteins produced by the immune system that bind to white blood cells called neutrophils, ultimately triggering an autoimmune reaction. As a result, researchers contend that ANCA testing should not be used as the only criteria…

Tavneos (avacopan) reduced respiratory, ear, nose, and throat (ENT) involvement among people with ANCA-associated vasculitis (AAV), but did not significantly outperform prednisone in its ability to do so, according to a substudy of the larger Phase 3 ADVOCATE trial. The treatment also significantly lowered patients’ reliance on glucocorticoid…

People with a past history of autoimmune disease before developing ANCA-associated vasculitis (AAV) have significantly fewer relapses after achieving remission, a study reported. Post-remission chances of a relapse were 67% lower in these AAV patients and took longer to occur, findings showed. Its researchers argued that these results support a…

Rituximab treatment led to rates of remission and relapse prevention in Mexican patients with ANCA-associated vasculitis (AAV) that were similar to those previously observed in other patient populations, a real-world study found. It was also associated with a higher rate of infections, the study found. Overall, about 65% of…

People with rheumatoid arthritis (RA) who also have ANCA-associated vasculitis (AAV) are more likely to develop signs of kidney impairment than those without AAV, a small study showed. Among patients with both disorders, AAV was usually diagnosed after RA, and often was asymptomatic, highlighting that an early RA diagnosis…