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Blood levels of several proteins — CXCL13, interleukins IL-6, IL-8, IL-15, IL-18 binding protein (IL-18BP), matrix metalloproteinase-3 (MMP-3), and erythrocyte sedimentation rate (ESR) — were validated as effective at identifying active ANCA-associated vasculitis (AAV) in a long-term study. The study, “Serum Biomarkers of Disease Activity in Longitudinal Assessment…

Outcomes of kidney transplants for children with kidney failure related to ANCA-associated vasculitis (AAV) are comparable to outcomes of transplants for children with other causes of kidney disease, highlighting that the procedure is generally safe and effective for children with AAV. That’s according to the study “…

People with ANCA-associated vasculitis (AAV) have a higher risk of cardiovascular disease, especially in the months immediately following AAV diagnosis, a population-based analysis found. “Our study demonstrates a key ‘high-risk window’ that should prompt careful monitoring for CV [cardiovascular] disease and aggressive risk factor reduction,” the scientists said. The…

People over the age of 65 with ANCA-associated vasculitis (AAV) have worse mortality outcomes than younger patients, but kidney failure is not greater in this group, according to a recent study. These worse outcomes were associated with lower levels of hemoglobin — the protein responsible for carrying oxygen in…

People with ANCA-associated vasculitis (AAV) adopt a range of strategies that help them to better cope with the condition on their own, but several areas of self-management could be addressed more immediately through conversations with their physicians, a study found. The study, “Addressing the transition to a chronic…

The case of a man in Saudi Arabia with granulomatosis with polyangiitis (GPA), a form of ANCA-associated vasculitis, highlights the difficulties that can occur in diagnosing this disease, a case study reports. The report is one of the few documented instances of GPA in Saudi Arabia. The study, “…

Blood levels of progranulin — a protein involved in cell development, cell growth, and wound healing — may predict the severity of ANCA-associated vasculitis (AAV), a new observational study suggests. According to researchers, serum progranulin, or the protein’s levels in the bloodstream, “could be used as a predictive marker…

Plasma exchange and extracorporeal membrane oxygenation or ECMO — the use of an artificial lung — are two interventions that may benefit patients with severe ANCA-associated vasculitis (AAV) linked with pulmonary hemorrhage, a potentially life-threatening condition in which blood starts to build up in the lungs, a case…

Over 230 national organizations signed a letter urging all 50 U.S. state governors to “maintain and expand” flexibility with licensure requirements for the duration of the COVID-19 pandemic to ease access to care. During the pandemic, governors used emergency authority to waive certain state licensure requirements, giving healthcare providers…

A committee of the European Medicines Agency has recommended approving Tavneos (avacopan) as an add-on therapy for adults with severe, active microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA), the two most common types of ANCA-associated vasculitis. This recommendation from the Committee for Medicinal Products for Human Use…