News

Eosinophilic granulomatosis with polyangiitis (EGPA) patients treated at private practices in the U.S. have high disease burden associated with multiple symptoms and simultaneous health conditions, a study showed, mirroring findings reported for patients treated at academic settings. Patients treated in private practice demonstrated variable responses to standard treatments, with some patients…

Machine learning based on clinicians’ notes found in electronic health records accurately identifies cases of ANCA-associated vasculitis (AAV), a study demonstrated. The model was found to be superior to traditional algorithms based on diagnostic codes with or without medication use at identifying AAV cases. “Its application to EHR [electronic…

A graphic prediction tool may accurately estimate the chance of survival over two years in people ANCA-associated vasculitis (AAV), according to a study at a single Chinese hospital. The tool, a nomogram based on 16 predictive factors, was able to differentiate patients who survived from those who didn’t with…

The likelihood of disease recurrence in people with anti-neutrophilic cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) varies by disease type, with those with granulomatosis with polyangiitis (GPA) more likely to see their disease come back following successful treatment than people with microscopic polyangiitis (MPA), a study found. Patients with MPA may be…

Plasma exchange added to standard immunosuppressive treatments helps improve early kidney function in people with ANCA-associated vasculitis (AAV) who have glomerulonephritis, an inflammation of the kidneys’ filtering units, reducing the risk of kidney failure within the first year. That’s according to a new analysis of data from the…

Intravenous immunoglobulin (IVIg) therapy can reduce relapses and lessen long-term disability in people with eosinophilic granulomatosis with polyangiitis (EGPA), a rare form of ANCA-associated vasculitis (AAV), a study from Italy has found. At patients’ one-year follow-up after IVIg treatment, reductions in peripheral neuropathy — damage to nerves outside…

Physicians typically do not overestimate the overall health of people with ANCA-associated vasculitis (AAV), a study of global assessments made by patients and their doctors in Australia reports. In cases where ratings between these two groups markedly differed, doctors tended to assign a lower score than did the people…

Lixudebart (ALE.F02), an experimental therapy Alentis Therapeutics is developing to help preserve kidney health in ANCA-associated vasculitis (AAV), showed a favorable safety profile in a Phase 2 clinical trial, the company has announced. A separate study testing lixudebart in people with liver disease also showed a good safety…

Adicet Bio has pushed to the second half of 2025 the expected timing for enrolling patients with ANCA-associated vasculitis (AAV) in an ongoing Phase 1 clinical trial testing ADI-001, an experimental CAR T-cell therapy for a number of autoimmune diseases. The company had said it expected enrollment…

Most children with ANCA-associated vasculitis (AAV) and kidney involvement at diagnosis will exhibit inactive kidney disease after one year, and more than two in five will show evidence of permanent kidney damage, according to data from an international registry study. A glomerular filtration rate (eGFR) — a standard measure…