Blood tests that look for the anti-neutrophil cytoplasmic autoantibodies (ANCAs) that cause ANCA-associated vasculitis (AAV) may help identify patients with kidney involvement, a study shows. Still, ANCA testing was not as accurate for this purpose as a kidney biopsy, wherein a small piece of kidney tissue is collected…
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Researchers have identified a set of clinical red flags that could help detect eosinophilic granulomatosis with polyangiitis (EGPA), the rarest type of ANCA-associated vasculitis (AAV). Among the red flags are specific high-level thresholds of eosinophils, a type of immune cell, combined with other signs including asthma, nasal polyps,…
About 1 in 10 people with idiopathic interstitial pneumonia (IIP), a condition marked by lung scarring of an unknown cause, who test positive for antineutrophil cytoplasmic antibodies, or ANCAs, eventually develop ANCA-associated vasculitis (AAV), a study shows. These patients’ risk factors for AAV include testing positive for ANCAs against…
NorthStar Medical Radioisotopes will sponsor an investigator-initiated research program focusing on the use of radioisotopes in diagnosing and treating ANCA-associated vasculitis (AAV), among other program goals. A radioisotope, or radioactive isotope, is an unstable form of a chemical element that releases radiation to return to a more stable…
Eye symptoms related to ANCA-associated vasculitis (AAV) are most common among those with granulomatosis with polyangiitis (GPA), affecting more than one-third of these patients, a new study from China showed. “These insights collectively underscore the importance of consistent ocular [eye-related] assessments for AAV patients, enabling the monitoring of disease…
Adding Tavneos (avacopan) to standard maintenance treatment safely and effectively promotes disease remission in ANCA-associated vasculitis (AAV) patients, according to a real-world study involving five German centers. In fact, remission rates after one year of Tavneos treatment were higher than those reported in the Phase 3 ADVOCATE…
Using benralizumab — a medication approved in the U.S. for a rare type of asthma — off-label as an add-on to standard induction treatment resulted in a high rate of disease remission in people with eosinophilic granulomatosis with polyangiitis (EGPA) and severe asthma. That’s according to a real-world study in…
The production of new B-cells, a type of immune cell that helps fight infections but is also involved in the abnormal immune attacks that drive ANCA-associated vasculitis (AAV), is dysfunctional in people with the autoimmune disease, a study found. The findings could help shed light on the biological underpinnings…
ANCA-associated vasculitis (AAV) patients with neurological manifestations are more than three times more likely to have large blood vessel involvement (LVI), according to a multicenter study in France and Belgium. Data also showed that LVI most commonly affected the aorta — the large artery that delivers oxygen-rich blood to…
While it’s rare in children, ANCA-associated vasculitis (AAV)-related glomerulonephritis, that is, an inflammation of the glomeruli, the kidneys’ filtering units, is associated with high rates of kidney failure or death, a study shows. Also, scar tissue accumulating in the glomeruli, other kidney tissue abnormalities, and high protein levels in…
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