News

In a Phase 3 trial of Tavneos (avacopan) in people with ANCA-associated vasculitis (AAV), the therapy’s effectiveness in the subgroup of patients on standard induction treatment with rituximab was similar to that of the overall study population. Reasonable safety also was seen, and sustained one-year remission was higher…

An 18-month fixed-schedule maintenance regimen of rituximab is better at keeping ANCA-associated vasculitis (AAV) in remission for up to seven years than azathioprine or a rituximab regimen tailored to an individual, according to pooled data from the Phase 3 MAINRITSAN program. Doubling the length of this fixed-schedule regimen did…

A Phase 2 clinical trial testing Q32 Bio’s ADX-097 in people with ANCA-associated vasculitis (AAV) will be the result of a recently announced merger between the company and Homology Medicines. While further details on the trial were not disclosed, results are expected in the second half of…

About one-quarter of adults with ANCA-associated vasculitis (AAV) in which their lungs are affected have small airway disease (SAD), which targets the tiny airways in the lungs, according to a study in China. Younger age, the presence of clumps of inflammatory cells called granulomas in the lungs, and other…

The U.S. Food and Drug Administration has approved Sana Biotechnology’s investigational new drug (IND) application requesting a Phase 1 clinical trial of its investigational cell therapy SC291 in people with ANCA-associated vasculitis (AAV) and other autoimmune diseases. “Our goal is to develop SC291 for patients with multiple…

In rare cases, ANCA-associated vasculitis (AAV) can result in muscle weakness that affects mainly the trunk and the muscles closest to the trunk due to blood vessel inflammation within the muscles, a study shows. Comprehensive tests of four AAV patients with this distinct clinical feature show that muscle symptoms…

People with ANCA-associated vasculitis (AAV) that affects their kidneys are at a significantly increased risk of kidney failure if they show a high proportion of inflamed glomeruli (the organ’s filtering units) on biopsies collected at diagnosis, a study has found. The study, “Renal histopathological predictors of…

High blood levels of the immune protein C4 are significantly associated with greater kidney-specific disease activity and a higher chance of developing kidney failure with microscopic polyangiitis (MPA), the most common type of ANCA-associated vasculitis (AAV), a study shows. For this reason, measuring blood C4 levels may help predict…

Nearly all ANCA-associated vasculitis (AAV) patients undergoing a bronchoscopy — a minimally invasive procedure to examine the lungs and air passages — at disease onset show lung involvement, a study reported. Bleeding from the alveoli, the tiny air sacs in the lungs where gases are exchanged, also was the most…

Blood levels of ANCAs — the disease-causing antibodies that give ANCA-associated vasculitis (AAV) its name — can be used to help distinguish AAV from other conditions in which ANCAs might also be present, a study showed. Higher levels of the antibodies at diagnosis also were significantly tied to greater…