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January 17, 2019

Patient Develops AAV Due to Familial Mediterranean Fever, Case Study Shows

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Blood vessel inflammation caused by ANCA antibodies should be considered in the differential diagnosis of familial Mediterranean fever with hyperthyroidism, a case study shows. The study, “Antineutrophil cytoplasmic antibody-positive ... Read more

January 15, 2019

Case Report Shows for First Time That AAV May Also Affect Brain, Spinal Cord

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Researchers reported for the first time the case of a patient with ANCA-associated vasculitis whose condition caused bleeding in the brain and spinal cord, most likely because of a ... Read more

January 14, 2019

Omalizumab May Reduce Asthma Symptoms and Steroid Requirement in EGPA Patients, Study Shows

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Omalizumab, an injectable medication approved for allergic asthma, might reduce asthma symptoms and steroid dosages in patients with eosinophilic granulomatosis with polyangiitis (EGPA), according to a retrospective study. The study, “Omalizumab in ... Read more

January 10, 2019

Rare Case of GPA/EGPA Overlap Syndrome Highlights Importance of Early Diagnosis

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Early identification of granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA) overlap is critical for prognosis, long-term treatment, and management of these two distinct diseases, a case ... Read more

January 8, 2019

Study Finds 3 Gene Variants Linked with Poor Outcomes in AAV Patients

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Patients with ANCA-associated vasculitis (AAV) carrying specific variants of the glucocorticoid receptor (GR) gene NR3C1 have a greater risk of death and of developing end-stage renal disease, according to ... Read more

January 7, 2019

European Union Approves Phase 2 Trial Testing IFX-1 in AAV Patients

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InflaRx will soon launch a Phase 2 clinical trial in Europe to assess the safety and effectiveness of IFX-1 — an investigational inhibitor of the complement system — in patients with ANCA-associated ... Read more

January 3, 2019January 3, 2019

Rare Case of Azathioprine-induced Skin Reaction Seen in AAV Patient in Case Study

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Azathioprine an oral immunosuppressant used as a maintenance therapy for ANCA-associated vasculitis (AAV) patients — may in rare cases cause a hypersensitive reaction of tender, red bumps on the skin, called ... Read more

December 21, 2018December 21, 2018

Rising Healthcare Costs Strain EU Budgets Even as New Therapies Flourish

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Cash-strapped governments across the 28-member European Union are struggling to control runaway healthcare expenditures — at exactly the same time as the promise of new but expensive therapies to ... Read more

December 18, 2018

Another Case of AAV Caused by Blood Pressure Medication Hydralazine Reported

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Hydralazine, a medication commonly used to lower blood pressure, may in rare cases cause ANCA-associated vasculitis (AAV), a new case report shows. The study, “Hydralazine-induced MPO-ANCA Renal-Limited Vasculitis Masquerading ... Read more

December 13, 2018

CD64 Levels in Neutrophils Distinguish Infection From Active Disease in AAV, Lupus, Study Reports

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Elevated levels of the CD64 protein on the surface of neutrophils – a type of immune cell – accurately distinguishes bacterial infection from disease flares in patients with ANCA-associated ... Read more

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