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October 17, 2019October 17, 2019

AAV Linked to Bleeding and Iron Deposits in Lungs in Case Study

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ANCA-associated vasculitis (AAV) can cause recurrent bleeding in the lungs, which manifest as hemosiderosis — an excessive accumulation of iron deposits in tissues — and lung nodules, a case ... Read more

October 16, 2019

Repeated Doses of Rituximab May Improve AAV Patients’ Response to the Medication, Study Suggests

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Administering rituximab repeatedly may improve the response of patients with ANCA-associated vasculitis (AAV) to the medication, a study says. The findings were reported in the study, “Non‐Linear Rituximab Pharmacokinetics ... Read more

October 10, 2019

Bacterial Infections, Especially in Lungs, Common in AAV Patients in Southern China, Study Reports

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Infection is a common complication of ANCA-associated vasculitis (AAV) that tends to develop within six months of diagnosis, and in cases of “mixed” infections — those caused by more ... Read more

October 8, 2019

Childhood Onset AAV Affects Multiple Organs at Diagnosis, May Be Managed with Rituximab, Study Suggests

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ANCA-associated vasculitis (AAV) with childhood onset often affects multiple organs, showing symptoms at diagnosis in the ear, nose, and throat, as well as pulmonary and renal complications, a single-center ... Read more

October 7, 2019October 7, 2019

No Benefit in Add-on Pulse Methylprednisolone for AAV Patients Needing Dialysis, Study Finds

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Adding methylprednisolone pulse therapy to standard induction therapy does not appear to have any particular benefit for people with severe ANCA-associated vasculitis (AAV) who need dialysis, a study suggests. ... Read more

October 3, 2019October 3, 2019

AAV Patients on Immunosuppressants at Higher Risk of Cancer, Especially Skin Cancer, Swedish Study Finds

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People with ANCA-associated vasculitis (AAV) are much more likely to develop a type of skin cancer called squamous cell carcinoma — nearly 13 times more likely — than those ... Read more

October 1, 2019October 4, 2019

FDA Approves Rituxan for Children and Adolescents with GPA, MPA

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The U.S. Food and Drug Administration (FDA) has approved Rituxan (rituximab), in combination with glucocorticoids, for the treatment of children ages two or older with granulomatosis with polyangiitis (GPA) ... Read more

September 30, 2019September 30, 2019

Low-dose Glucocorticoid Regimen May Effectively Treat AAV in Elderly Patients, Study Suggests

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A low-dose glucocorticoid regimen, in which intravenous methylprednisolone (a type of steroid) is not routinely used, can be used to effectively treat ANCA-associated vasculitis in elderly patients, a new study ... Read more

September 27, 2019

NORD 2019 Rare Disease Summit Set for Oct. 21-22 in Washington, DC

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Next month’s annual conference of the National Organization for Rare Disorders (NORD) in Washington, D.C., couldn’t come at a better time, says Marshall Summar, MD, chairman of NORD’s board ... Read more

September 26, 2019

AAV Patients Treated with Immunosuppressive Therapy More Likely to Develop Infectious Complications

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Patients with ANCA-associated vasculitis (AAV) treated with immunosuppressive agents have a higher risk of developing infectious complications, including pneumonia, sepsis, and fungal infection, a new study shows. The study, ... Read more

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