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April 24, 2018April 24, 2018

Some Patients with Hydralazine-related AAV Develop Advanced Kidney Disease, Study Finds

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Some patients with ANCA-associated vasculitis (AAV) caused by hydralazine — a medication used to treat high blood pressure — develop end-stage kidney disease, even after discontinuing the medicine and receiving immunosuppressive therapy, ... Read more

April 23, 2018April 23, 2018

Treatment for Severe Acne May in Rare Cases Cause AAV, Patient Study Shows

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Isotretinoin, a medication used to treat severe acne, may in rare instances lead to ANCA-associated vasculitis (AAV), according to the case report of a 15-year-old boy. The study, “Perinuclear ... Read more

April 19, 2018April 19, 2018

Low Immune Protein Levels Predict Worse ANCA-associated Vasculitis Survival, Study Finds

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Low levels of two immune system proteins increase the risk that a person who has just been diagnosed with ANCA-associated vasculitis will die or have a serious kidney problem, a ... Read more

April 17, 2018

Avacopan Safer, More Effective than Standard Therapy in AAV Patients, Phase 2 Trials Show

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Patients with ANCA-associated vasculitis (AAV) have fewer adverse events and better quality of life when treated with avacopan over standard therapy, results from two Phase 2 clinical trials show. ... Read more

April 16, 2018April 16, 2018

Azathioprine Therapy in AAV Patients Not Affected by TPMT Enzyme Activity, Study Shows

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Compared to patients with inflammatory bowel disorders, the safety and efficacy of azathioprine treatment in ANCA-associated vasculitis (AAV) patients is not affected by lower TPMT protein activity, researchers found. ... Read more

April 13, 2018April 12, 2018

NIH Agency Pioneers Collaborative Research into Rare Diseases

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A little-known government entity within the National Institutes of Health (NIH) is helping to lead U.S. efforts to speed up the development of therapies for some 7,000 rare diseases. ... Read more

April 12, 2018

Faulty Immune System Component in AAV Leads to Neutrophil Activation, Kidney Damage, Study Shows

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A faulty immune system component in patients with active ANCA-associated vasculitis (AAV) is not equipped to stop ANCA-induced neutrophil activation, leading to kidney damage, a Chinese study shows. The component ... Read more

April 10, 2018

Study Links White Blood Cell Precursors to Vasculitis Severity at Diagnosis

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The more white blood cell precursors that an ANCA-associated vasculitis (AAV) patient has when diagnosed, the worse their disease, a South Korean study reports. Levels of the precursors, known as ... Read more

April 9, 2018April 11, 2018

FDA Approves AESKU’s Automated Diagnostic Tests for ANCA-associated Vasculitis

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The U.S. Food and Drug Administration has approved two automated diagnostic tests that AESKU.Group developed for ANCA-associated vasculitis. AESKU used its HELIOS technology to develop the tests. HELIOS is the only diagnostic tool ... Read more

April 5, 2018

Rare Mutations in ATT Protein May Lead to Development of AAV, Case Report Suggests

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ANCA-associated vasculitis (AAV) may be associated with rare mutations in the alpha-1 antitrypsin (AAT) protein, a new case report suggests. The study, “Fulminant hepatic failure in the setting of progressive ... Read more

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