Marisa Wexler, MS, senior science writer —

Marisa holds a Master of Science in cellular and molecular pathology from the University of Pittsburgh, where she studied novel genetic drivers of ovarian cancer. Her areas of expertise include cancer biology, immunology, and genetics, and she has worked as a science writing and communications intern for the Genetics Society of America.

Articles by Marisa Wexler

Complement protein in blood may predict kidney damage in MPA

High blood levels of the immune protein C4 are significantly associated with greater kidney-specific disease activity and a higher chance of developing kidney failure with microscopic polyangiitis (MPA), the most common type of ANCA-associated vasculitis (AAV), a study shows. For this reason, measuring blood C4 levels may help predict…

Low-dose glucocorticoids just as effective for long-term AAV control

A treatment regimen that combines low-dose glucocorticoids and rituximab is just as effective at controlling ANCA-associated vasculitis (AAV) as a standard regimen of high-dose glucocorticoids and rituximab, according to two-year data from a clinical trial. The long-term findings indicate that, while the efficacy is comparable, the risk of serious…

New statistical model predicts AAV prognosis with good accuracy

A new statistical model that considers age, disease type, patterns of organ involvement, and lab findings may help predict long-term survival in ANCA-associated vasculitis (AAV) better than available prognostic systems, a study suggests. The study “Development and internal validation of a model to predict long-term survival of ANCA…

EGPA symptoms differ by patients’ antibody type, study suggests

Different types of disease-driving antibodies tend to associate with different symptoms of eosinophilic granulomatosis with polyangiitis (EGPA), the rarest form of ANCA-associated vasculitis. That’s according to the study “Spectrum of ANCA-specificities in eosinophilic granulomatosis with polyangiitis. A retrospective multicenter study,” published in Clinical and Experimental Rheumatology.

AAV genetic risk factors may differ according to sex: Study

Women carrying a genetic mutation dubbed rs9274619 have a significantly higher risk of ANCA-associated vasculitis (AAV) associated with antibodies against myeloperoxidase (MPO) than men, a new study shows. Among MPO-AAV patients, this mutation was linked to a greater likelihood of eye involvement and a lower risk of lung involvement.