A case report of a patient with granulomatosis with polyangiitis (GPA) along with ocular involvement suggests that Rituxan (rituximab) might be successful for people who don’t respond to prednisolone and cyclophosphamide. The study, “Peripheral Ulcerative Keratitis Associated with Granulomatosis with Polyangiitis Emerging Despite Cyclophosphamide, Successfully Treated with Rituximab,”…
Rituxan (rituximab) treatment is effective in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) who failed to respond to standard immunosuppressors, results from a Turkish study suggest. But the team at Istanbul University noted that key data on its use — especially long-term data — is still lacking. The…
Researchers have identified a fat molecule that contributes to kidney damage in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, or AAV. The molecule, sphingosine 1-phosphate (S1P), works to enhance the damaging effects of MPO autoantibodies, one of the two most common disease-causing antibodies produced by AAV patients. The study, “…
ANCA vasculitis may trigger inflammation in large blood vessels as well as the small ones the disease is associated with, Japanese researchers reported after noting that three patients had developed an aortic aneurysm. These patients had ANCA vasculitis caused by myeloperoxidase (MPO) antibodies. An aneurysm is an enlarged segment of the…
Patients with severe kidney injury stemming from anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) may benefit from intravenous glucocorticoid pulses, a study indicates. The high-dose treatment helped Chinese patients get off dialysis and showed a tendency toward increasing their survival, researchers found. They published their findings in the journal BMC Nephrology.
A retrospective study has found an association between the length of prodromal phase – where patients experience non-specific symptoms before more specific disease signs develop – and mortality in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients. This finding underscores the importance of early diagnosis. The study, “Relation…
The European Medicines Agency (EMA) has accepted for review ChemoCentryx’s application to approve Avacopan (CCX168) as a treatment for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. The company, with its partner Vifor Fresenius Medical Care Renal Pharma, applied for a Conditional Marketing Authorization (CMA) of the medicine. A CMA…
Rituxan (rituximab) effectively induces and maintains remission in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), a new Saudi study shows. The study, “Systematic review of the role of rituximab in treatment of antineutrophil cytoplasmic autoantibody-associated vasculitis, hepatitis C virus-related cryoglobulinemic vasculitis, Henoch-Schönlein purpura, ankylosing spondylitis, and…
Many ANCA-associated vasculitis patients who have a certain type of autoantibody develop the widened-airway condition known as bronchiectasis, a French study shows. The question of whether the respiratory tract is the place where ANCA-associated vasculitis develops remains to be seen, however, the researchers said. The hallmark of ANCA-associated vasculitis is…
Patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) who receive daily oral cyclophosphamide have increased bone marrow toxicity and tend to be hospitalized more often because of infections, than patients who receive the treatment intravenously. Those findings were detailed in the report “Long-term outcomes of daily oral vs. pulsed…
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