Nasal administration of niclosamide, a medication used in certain regions for intestinal tapeworm infections, may help reduce ear, nose, and throat (ENT) symptoms in people with ANCA-associated vasculitis (AAV). In particular, benefits were seen among individuals with self-reactive antibodies against the proteinase 3 (PR3) protein — one of the…
Tapeworm medication may ease ear, nose, throat symptoms in AAV
By the time this column is published, I’ll be a couple of weeks into recovering from a hip replacement. I am writing it in advance because I’m fairly certain I won’t have the wherewithal to write coherently after the surgery. I never imagined I’d need a hip replacement at this…
People with ANCA-associated vasculitis (AAV) have a significantly higher risk of developing certain blood and solid-organ cancers, compared with those without the rare autoimmune disease, according to a large real-world study in the U.S. The study examined the medical records of more than 18,000 people with AAV and a…
Dupilumab, an approved medication for diseases marked by high levels of the immune cell eosinophils, may help ease symptoms in people with eosinophilic granulomatosis with polyangiitis (EGPA), according to a study reporting on three patients. The therapy, sold as Dupixent, helped control asthma and atopic dermatitis — two conditions…
Valentine’s Day usually comes with a lot of noise. Flowers. Chocolate. Big romantic gestures. All of that is fine, but I want to offer a slightly different Valentine’s idea: one that feels especially right for those of us living with ANCA vasculitis. This year, let’s send valentines to the…
People with active granulomatosis with polyangiitis (GPA), the most common type of ANCA-associated vasculitis (AAV), had significantly higher levels of a specific type of immune cell called peripheral helper T (Tph) cells in their blood, a study found. Higher levels of circulating Tph (cTph) cells were also significantly linked…
Amgen said it declined a U.S. Food and Drug Administration (FDA) request to voluntarily withdraw Tavneos (avacopan), an oral treatment approved for the most common forms of ANCA-associated vasculitis (AAV), from the U.S. market. The FDA made the request because of concerns about the integrity of clinical…
A hip replacement is not as “simple” as some people might portray it. As many of you know, I recently had a total hip replacement. Before the surgery, people kept saying things like, “Oh, those are easy!” or “My neighbor was walking in a week!” And every time, I…
Children with ANCA-associated vasculitis (AAV) have higher numbers of two specific subsets of neutrophils, a type of immune cell implicated in AAV, that produce high levels of molecules linked to inflammation and other damaging processes, a small study showed. Notably, these overactive neutrophils appear to have difficulty processing glutamine,…
Following questions about the integrity of clinical trial data, regulators in Europe are taking a second look at Tavneos (avacopan), an oral therapy approved for ANCA-associated vasculitis (AAV). In a press release, the European Medicines Agency (EMA) announced that it “will now review all available data to…
Recent Posts
- Kidney tissue patterns may influence treatment response in AAV
- Chronic lung condition doubles infection risk in AAV patients: Study
- I often can’t breathe automatically due to lung issues and AAV
- New kidney risk score shows strong predictive power in AAV study
- Half of adults with AAV have interstitial lung disease at diagnosis, study finds