Real-world data show high AAV remission rates with Tavneos

Tavneos (avacopan), in combination with standard treatment, induced disease remission within six months in nearly all adults with ANCA-associated vasculitis (AAV), according to pooled results from 16 published real-world studies. Real-world remission rates with Tavneos at six months and one year were higher than those reported in the…

People with overlapping features of granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA), two types of ANCA-associated vasculitis, may exhibit distinct disease characteristics that influence disease severity and prognosis, a study reveals. By analyzing data from more than 100 people with overlapping GPA/EGPA features, a team…

A new year can feel complicated when living with ANCA vasculitis. For us, it’s not a clean slate, but rather a moment for reflection. We look back at what our bodies carried us through and look ahead with the quiet hope that this year might unfold a bit more…

Risk factors for relapse in ANCA-associated vasculitis (AAV) appear to differ depending on treatment phase, with higher levels of inflammation and immune activity linked to a greater risk of relapse after maintenance therapy is stopped. That’s according to a new, non-prespecified analysis of data from the Phase 3…

Holidays can be wonderful — full of joy, connection, and tradition. They can also be complicated, especially for those of us living with vasculitis. This season, I was reminded of the importance of sharing openly with the people we love about what this disease means in our day-to-day lives.

Small particles loaded with manganese, an essential trace mineral, may help protect the kidneys from damage related to ANCA-associated vasculitis (AAV) by restoring antioxidant defenses and blocking a form of immune-mediated cell death. These findings come from experiments using neutrophils isolated from the blood of people with ANCA-associated glomerulonephritis…

Blood levels of calprotectin and urine levels of soluble CD163, two biomarkers of inflammation and disease activity in people with ANCA-associated vasculitis (AAV), are elevated within the first six months following an AAV relapse, stabilizing thereafter. That’s according to a recent study in Spain that also showed levels of…

Living with ANCA vasculitis asks more of us than most people understand. It demands we become experts in our own bodies, pay attention to small shifts, and make decisions that most people never think twice about. And when your kidneys are part of the story, everything can feel even…

Measuring immune cells called eosinophils can help predict the presence and severity of peripheral neuropathy (damage to nerves outside the brain and spinal cord) in people with eosinophilic granulomatosis with polyangiitis (EGPA), a study showed. In people with one of the other two types of ANCA-associated vasculitis (AAV) —…

Using both traditional and data-driven ways of grouping patients may give a clearer, more accurate picture of how different types of ANCA-associated vasculitis (AAV) behave over time and how best to treat each person, according to a study from Japan. Traditional ways of classifying AAV, based on symptoms or…