ANCA-associated vasculitis (AAV) patients receiving a cumulative dose of at least 935 mg of glucocorticoids over six months are more likely to see clinically meaningful side effects, according to a study using calculations based on the Glucocorticoid Toxicity Index (GTI). The findings suggest the GTI, which considers the frequency…
Recruitment is continuing in three countries for a Phase 1b/2a clinical trial testing Alpine Immune Sciences’ povetacicept in adults with autoimmune conditions affecting the kidneys, including ANCA-associated vasculitis (AAV). Called RUBY-3 (NCT05732402), the early study is designed to enroll an estimated 56 patients, ages 18 and older,…
Last in a series. Read part one. In my previous column, I discussed how I plan for international trips with eosinophilic granulomatosis with polyangiitis (EGPA), a type of ANCA-associated vasculitis (AAV). Planning an international trip takes forethought and an awareness of potential pitfalls. Once you arrive at…
Two blood parameters — interleukin 8 (IL-8) and the neutrophil/lymphocyte ratio (NLR) — may help identify ANCA-associated vasculitis (AAV) patients with high disease activity and those at risk of poor prognosis, a single center study in China suggests. “IL-18 may be adopted as one of the important biological markers…
Piglet in the Winnie the Pooh series has a famous line: “It is hard to be brave when you’re only a Very Small Animal.” When I was diagnosed in April 2007 with eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome, it wasn’t…
The Renal Risk Score may be a better histopathologic classification model than Berden for predicting long-term loss of kidney function in people with ANCA-related vasculitis (AAV) who have glomerulonephritis, an inflammation of the kidneys’ filtering units, a study finds. Incorporating the renal risk score into clinical decision-making could help…
The Kidney Disease: Improving Global Outcomes (KDIGO) work group has released an updated practice guideline based on developments in how best to manage ANCA-associated vasculitis (AAV) associated with inflammation or damage to the kidneys. The guideline now offers advice on the use of lower doses of…
Biomarkers measured in blood or urine may help track disease activity and organ damage in people with ANCA-associated vasculitis (AAV), according to a systematic review study. AAV is an autoimmune disorder in which self-reactive antibodies called anti-neutrophil cytoplasmic antibodies (ANCAs) attack the body’s own neutrophils — a type of…
Fasenra (benralizumab), which is approved for a rare type of asthma, and Nucala (mepolizumab) were similarly effective at inducing remission in eosinophilic granulomatosis with polyangiitis (EGPA), but more people on Fasenra were able to stop using oral corticosteroids (OCS), with fewer monthly injections. That’s according to final published…
Occupational exposure to silica, one of the most common minerals in the earth’s crust, may lead to microscopic polyangiitis (MPA) — a type of ANCA-associated vasculitis — particularly in individuals with a genetic predisposition to autoimmune diseases, a case report suggests. Silica, found in sand and rocks, is known to…
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