News

Patients with ANCA-associated vasculitis (AAV) who have renal symptoms might benefit from a kidney biopsy along with measurements of ANCA antibodies and kidney function to predict their renal outcomes, a Chinese study reported. The study, “An evaluation of the 2010 histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis: a…

A case study from Japan found that patients with microscopic polyangiitis can, on rare occasions, develop aneurysms in their renal arteries, a complication that can lead to blood vessel rupture and sometimes death. The case report with the finding, “Ruptured renal artery in microscopic polyangiitis: a case report and…

Patients with granulomatosis with polyangiitis can rarely develop abdominal aortic aneurysm, a serious condition that can lead to blood vessel rupture and, in extreme circumstances, death. The case report with that finding, “Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case…

A kidney biopsy is valuable in establishing a diagnosis and prognosis for end-stage renal disease in older patients with ANCA-associated vasculitis who have kidney involvement, although they are not useful for predicting overall survival, a study shows. “Prognosis and Histological Classification in Elderly Patients with ANCA-Glomerulonephritis: A Registry-Based…

While rare, patients with scleroderma — a disease that causes skin hardening — can also develop ANCA-associated vasculitis, a case report shows. The study, “Perinuclear Antineutrophil Cytoplasmic Antibody Positive Glomerulonephritis in a Case of Limited Cutaneous Scleroderma,” was published in the Indian Journal of Nephrology.

Pregnant women who develop ANCA-associated vasculitis (AAV) may safely receive Rituxan (rituximab) and corticosteroids, a case study suggests. However, this is the first study describing Rituxan’s use in pregnant women with vasculitis, and researchers say more evidence of its safety and effectiveness  is needed. The study, “…

A deficiency in leptin — the hormone that signals the brain when a person has eaten enough — may lead to the development of ANCA-associated vasculitis (AAV), according to a new case study from India. The report, “ANCA-associated Vasculitis in a Case of Congenital Leptin Deficiency,” was published…

Excessive activation of a defense mechanism of neutrophils — key immune cells in ANCA-associated vasculitis (AAV) — is a potential biomarker for active disease, according to researchers. Their study, “Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA,” was published in the journal Kidney…

Treatment with a common antibiotic reduces the risk of life-threatening infections in ANCA-associated vasculitis patients being given Rituxan (rituximab) for their condition, a study conducted in the U.K. and Austria reports. This finding supports the use of the antibiotic trimethoprim-sulfamethoxazole in routine clinical practice for these patients.

InflaRx will soon begin a Phase 2 clinical trial assessing the safety and effectiveness of IFX-1 — an inhibitor of the complement system — in patients with ANCA-associated vasculitis (AAV). This follows the the U.S. Food and Drug Administration’s approval of the company’s investigational new drug application (IND). The Phase…