News

Fasenra, Nucala equally effective, safe in EGPA: Real-world study

Fasenra (benralizumab) and Nucala (mepolizumab) appear to be equally safe and effective in helping adults with eosinophilic granulomatosis with polyangiitis (EGPA) achieve disease remission, according to a real-world study in Europe that directly compared the two approved therapies. Still, at one year, AstraZeneca’s Fasenra was associated with…

Blood GDF15 levels at diagnosis seen as predicting outcomes

Blood levels of a signaling molecule called growth differentiation factor 15 (GDF15) at diagnosis may help predict poor outcomes, including kidney failure and death, in people with ANCA-associated vasculitis (AAV), according to a study in South Korea. Data also showed that GDF15 levels were significantly associated with AAV…

ANCA test may help tell MPA from GPA, study shows

Testing for the presence of specific self-reactive antibodies linked to ANCA-associated vasculitis (AAV) may help doctors more easily tell microscopic polyangiitis (MPA) from granulomatosis with polyangiitis (GPA), the two most common types of AAV, a study showed. Classifying patients as MPA or GPA based on the different types…

C4d protein may be biomarker of ANCA-associated vasculitis activity

People with ANCA-associated vasculitis (AAV) have significantly higher blood levels of C4d, a protein that reflects activation of the classic or lectin complement pathways of the immune system, a study in Sweden suggests. Patients with self-reactive antibodies, called ANCAs, against the proteinase-3 (PR3) protein had significantly higher blood Cd4…

Conduit secures US patent for potential AAV therapy AZD1656

The U.S. Patent and Trademark Office (USPTO) has granted Conduit Pharmaceuticals a patent for AZD1656, its experimental therapy for ANCA-associated vasculitis (AAV) and other autoimmune diseases. The USPTO granted a composition of matter patent, which is a type of patent that relates to novel compounds made from two or…

Long-term Nucala found well tolerated as EGPA treatment: Data

Long-term treatment with Nucala (mepolizumab) — approved for use in EGPA, or eosinophilic granulomatosis with polyangiitis, the rarest type of ANCA-associated vasculitis — appears to be well tolerated by most patients, and was seen to reduce or even eliminate corticosteroid use. That’s according to new data from an…

Disease symptoms in AAV vary by age at diagnosis, sex, study finds

Disease symptoms among people with ANCA-associated vasculitis (AAV) were found to vary by age at diagnosis and biological sex, according to data from more than 1,100 Scandinavian patients. “We identified significant differences in clinical presentation of the disease between female and male patients and between patients with a young…