News

Small particles loaded with manganese, an essential trace mineral, may help protect the kidneys from damage related to ANCA-associated vasculitis (AAV) by restoring antioxidant defenses and blocking a form of immune-mediated cell death. These findings come from experiments using neutrophils isolated from the blood of people with ANCA-associated glomerulonephritis…

Blood levels of calprotectin and urine levels of soluble CD163, two biomarkers of inflammation and disease activity in people with ANCA-associated vasculitis (AAV), are elevated within the first six months following an AAV relapse, stabilizing thereafter. That’s according to a recent study in Spain that also showed levels of…

Measuring immune cells called eosinophils can help predict the presence and severity of peripheral neuropathy (damage to nerves outside the brain and spinal cord) in people with eosinophilic granulomatosis with polyangiitis (EGPA), a study showed. In people with one of the other two types of ANCA-associated vasculitis (AAV) —…

Using both traditional and data-driven ways of grouping patients may give a clearer, more accurate picture of how different types of ANCA-associated vasculitis (AAV) behave over time and how best to treat each person, according to a study from Japan. Traditional ways of classifying AAV, based on symptoms or…

Older age, being male, smoking history, and having self-reactive antibodies targeting the myeloperoxidase (MPO) protein are significantly associated with a higher risk of interstitial lung disease (ILD) in people with ANCA-associated vasculitis (AAV). That’s according to a review and meta-analysis study, which also showed that certain imaging signs of…

Physicians experienced in treating ANCA-associated vasculitis (AAV) generally agree on which disease manifestations are driven by granulomas, or clusters of immune cells, according to a survey study. Such manifestations included masses on the lungs or behind the eye socket, narrowing of the airways below the vocal cords, and…

People with ANCA-associated vasculitis (AAV) who test positive for a staining pattern of self-reactive antibodies called cytoplasmic ANCA (C-ANCAs) are nearly five times more likely to have bleeding into the lungs’ air sacs, known as alveolar hemorrhage, a study found. C-ANCA is marked by the presence of ANCAs —…

In people with eosinophilic granulomatosis with polyangiitis (EGPA), those with skin or heart involvement have significantly higher blood levels of immunoglobulin E (IgE), a type of natural antibody frequently linked to EGPA, a study showed. Testing positive for the self-reactive antibodies ANCAs against the myeloperoxidase (MPO) protein tended to…

A protein known as NGAL — fully, neutrophil gelatinase-associated lipocalin — appears to be a marker of disease activity and kidney damage severity in people with ANCA-associated vasculitis (AAV) who have kidney inflammation, according to new research by scientists in China. The team found that “in active AAV, [blood]…

Two Phase 1/2 clinical trials testing NKX019 — Nkarta’s cell therapy candidate — are now enrolling participants to test a second, higher dose in people with ANCA-associated vasculitis (AAV) and other autoimmune conditions. The Ntrust-2 study (NCT06733935) is enrolling up to 144 people with AAV, idiopathic inflammatory…