Researchers have identified new contributors to the abnormal immune responses against the myeloperoxidase (MPO) enzyme that drive ANCA-associated vasculitis (AAV) in some patients. Specifically, these abnormal responses are marked by high numbers of memory B-cells that produce an antibody type called immunoglobulin M (IgM). Memory B-cells are immune cells crucial to…
The frequency of ANCA-associated vasculitis (AAV) among the Indigenous peoples of Alaska is high compared with other populations worldwide, especially the granulomatosis with polyangiitis (GPA) form of the disease, Â a study reports. Native Alaskans and American Indians in Alaska with AAV also may have more severe clinical features at…
Among ANCA-associated vasculitis (AAV) patients with kidney failure and waiting for a kidney transplant, undergoing the transplant reduces their risk of dying by more than half relative to continuing on dialysis, a replacement therapy. These findings, from a 20-year study of people in France with AAV listed for a…
Researchers in Japan have identified four distinct subtypes of microscopic polyangiitis, or MPA — a type of ANCA-associated vasculitis (AAV) — that are associated with different clinical characteristics, which may help in better predicting, and improving, patient outcomes, according to the team. One subtype was marked mainly by kidney…
A key sign of heart disease — calcium buildup in the blood vessels that supply the heart, known as coronary artery calcification — was found in a majority of adults with ANCA-associated vasculitis (AAV) in a study by U.S. researchers. Such calcium deposits are associated with atherosclerosis, or the…
Machine learning based on clinicians’ notes found in electronic health records accurately identifies cases of ANCA-associated vasculitis (AAV), a study demonstrated. The model was found to be superior to traditional algorithms based on diagnostic codes with or without medication use at identifying AAV cases. “Its application to EHR [electronic…
A new Phase 3 clinical trial is recruiting children and adolescents with active granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA), the most common types of ANCA-associated vasculitis (AAV), to test Tavneos (avacopan) in combination with rituximab or cyclophosphamide. That’s according to a financial update released by…
Low blood levels of the copper-carrying protein ceruloplasmin at diagnosis are associated with worse survival in adults with ANCA-associated vasculitis (AAV) who test positive for self-reactive antibodies against the myeloperoxidase (MPO) enzyme, a new study from France has shown. “This is the first study associating low [blood] ceruloplasmin level…
About 1 in 10 people with idiopathic interstitial pneumonia (IIP), a condition marked by lung scarring of an unknown cause, who test positive for antineutrophil cytoplasmic antibodies, or ANCAs, eventually develop ANCA-associated vasculitis (AAV), a study shows. These patients’ risk factors for AAV include testing positive for ANCAs against…
NorthStar Medical Radioisotopes will sponsor an investigator-initiated research program focusing on the use of radioisotopes in diagnosing and treating ANCA-associated vasculitis (AAV), among other program goals. A radioisotope, or radioactive isotope, is an unstable form of a chemical element that releases radiation to return to a more stable…
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