Facial palsy, or weakness of the facial muscles, is associated with a nearly 10 times higher risk of hearing loss with granulomatosis with polyangiitis (GPA), a type of ANCA-associated vasculitis (AAV), a single-center study suggests. Older age, along with ear or eye involvement, were also significant risk factors for…
Researchers have identified new contributors to the abnormal immune responses against the myeloperoxidase (MPO) enzyme that drive ANCA-associated vasculitis (AAV) in some patients. Specifically, these abnormal responses are marked by high numbers of memory B-cells that produce an antibody type called immunoglobulin M (IgM). Memory B-cells are immune cells crucial to…
The frequency of ANCA-associated vasculitis (AAV) among the Indigenous peoples of Alaska is high compared with other populations worldwide, especially the granulomatosis with polyangiitis (GPA) form of the disease, Â a study reports. Native Alaskans and American Indians in Alaska with AAV also may have more severe clinical features at…
Among ANCA-associated vasculitis (AAV) patients with kidney failure and waiting for a kidney transplant, undergoing the transplant reduces their risk of dying by more than half relative to continuing on dialysis, a replacement therapy. These findings, from a 20-year study of people in France with AAV listed for a…
Researchers in Japan have identified four distinct subtypes of microscopic polyangiitis, or MPA — a type of ANCA-associated vasculitis (AAV) — that are associated with different clinical characteristics, which may help in better predicting, and improving, patient outcomes, according to the team. One subtype was marked mainly by kidney…
A key sign of heart disease — calcium buildup in the blood vessels that supply the heart, known as coronary artery calcification — was found in a majority of adults with ANCA-associated vasculitis (AAV) in a study by U.S. researchers. Such calcium deposits are associated with atherosclerosis, or the…
Machine learning based on clinicians’ notes found in electronic health records accurately identifies cases of ANCA-associated vasculitis (AAV), a study demonstrated. The model was found to be superior to traditional algorithms based on diagnostic codes with or without medication use at identifying AAV cases. “Its application to EHR [electronic…
A new Phase 3 clinical trial is recruiting children and adolescents with active granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA), the most common types of ANCA-associated vasculitis (AAV), to test Tavneos (avacopan) in combination with rituximab or cyclophosphamide. That’s according to a financial update released by…
Low blood levels of the copper-carrying protein ceruloplasmin at diagnosis are associated with worse survival in adults with ANCA-associated vasculitis (AAV) who test positive for self-reactive antibodies against the myeloperoxidase (MPO) enzyme, a new study from France has shown. “This is the first study associating low [blood] ceruloplasmin level…
About 1 in 10 people with idiopathic interstitial pneumonia (IIP), a condition marked by lung scarring of an unknown cause, who test positive for antineutrophil cytoplasmic antibodies, or ANCAs, eventually develop ANCA-associated vasculitis (AAV), a study shows. These patients’ risk factors for AAV include testing positive for ANCAs against…
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