Margarida Maia, PhD, science writer —

Tavneos (avacopan) improved kidney function and reduced the need for the glucocorticoid prednisone in four older patients who had signs of kidney failure due to ANCA-associated vasculitis (AAV), researchers in Canada report. While Tavneos may help patients enter into remission without the harmful side effects of glucocorticoids, “more…

Certain clotting markers are found at higher levels in the blood of people with ANCA-associated vasculitis (AAV) when their disease is active than when it’s in remission and symptoms ease or disappear, a study finds. Too much clotting may explain why people with active AAV are at increased risk…

A higher eosinophil count at diagnosis is linked to more severe disease activity in people with microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA), the two most common types of ANCA-associated vasculitis (AAV), a study suggests. Counting eosinophils, white blood cells that usually release enzymes and other molecules in…

Evotec has formed a partnership with Charité – Universitätsmedizin Berlin in Germany to build a database of all sorts of molecular information from people with ANCA-associated vasculitis (AAV). Molecular profiles, a kind of fingerprint of AAV, may help scientists better understand the autoimmune disease and pave the way…

Factor XII (FXII), a protein involved in blood clotting, is found at significantly higher levels in the blood of people with active ANCA-associated vasculitis (AAV) relative to those in clinical remission, or whose symptoms have eased or disappeared. That’s according to a study in China that also found that…

ANCA-associated vasculitis (AAV) patients who are older and taking pulses of methylprednisolone as an induction therapy are more likely to have a greater drop in protective IgG antibody levels during maintenance therapy with rituximab, raising a significant risk of severe infections, a study from France reports. A lower…

Common variants in genes that encode proteins of the alternative complement pathway, a part of the immune system, may raise the risk of ANCA-associated vasculitis (AAV) and severe disease-related kidney damage, a study shows. Researchers also found a link between worse disease outcomes and AAV…

An 18-month fixed-schedule maintenance regimen of rituximab is better at keeping ANCA-associated vasculitis (AAV) in remission for up to seven years than azathioprine or a rituximab regimen tailored to an individual, according to pooled data from the Phase 3 MAINRITSAN program. Doubling the length of this fixed-schedule regimen did…

A Phase 2 clinical trial testing Q32 Bio’s ADX-097 in people with ANCA-associated vasculitis (AAV) will be the result of a recently announced merger between the company and Homology Medicines. While further details on the trial were not disclosed, results are expected in the second half of…

Granulomatosis with polyangiitis (GPA) is the most common type of ANCA-associated vasculitis (AAV) in Italy and is linked to worse symptoms and higher mortality and healthcare costs than microscopic polyangiitis (MPA), another common AAV type, a study finds. Using immunosuppressive glucocorticoids was also associated with higher costs…