Most patients with eosinophilic granulomatosis with polyangiitis (EGPA) test positive for anti-neutrophil cytoplasmic autoantibodies (ANCAs) in sputum samples, even if they show no signs of them in their blood, researchers from Canada and the United States found. These patients have more severe lung involvement, the study shows, suggesting that measuring…
Patients with ANCA-associated vasculitis (AAV) are more likely to exhibit severe disease and experience poor kidney outcomes if they have low levels of the C3 complement protein at diagnosis, a study found. Researchers said the findings will help doctors identify AAV patients with severe disease and select appropriate treatment at…
More than 700 medical experts, pharmaceutical executives, patient advocates, and others are expected to converge on Washington, D.C., next month for the 2018 NORD Rare Diseases & Orphan Products Breakthrough Summit. The Oct. 15-16 event, sponsored by the National Organization for Rare Diseases (NORD), takes place at the…
A patient taking Imuran (azathioprine) to treat his ANCA-associated vasculitis experienced an acute allergic reaction to the therapy which manifested as a kidney inflammation. Researchers should be aware of this complication to promptly distinguish disease relapse from acute reactions to the medicine. The case report, “Azathioprine-induced interstitial nephritis…
In patients with interstitial lung disease, cigarette smoking may sometimes cause the production of ANCA associated antibodies — a hallmark of ANCA-associated vasculitis — without any signs of vessel inflammation, the case of a 57-year-old man suggests. The case report, “Combined pulmonary fibrosis and emphysema with myeloperoxidase-antineutrophil cytoplasmic antibody…
Alterations in the nasal cavity mucosa and throat often are primary symptoms of granulomatosis with polyangiitis (GPA) and it is critical that otolaryngologists are aware of the disease’s head and neck manifestations, researchers say. In a case report, Mayo Clinic researchers highlight some common endoscopic and radiologic findings seen…
Antiviral therapy prevents silent reactivation of cytomegalovirus (CMV) in ANCA-associated vasculitis (AAV) patients and improves patients’ immune responses, a proof-of-concept clinical study shows. These results suggest that antiviral therapy may reduce the risk of infection in these patients. The study, “Subclinical Reactivation of Cytomegalovirus Drives CD4+CD28null T-Cell Expansion…
Patients with ANCA-associated vasculitis who have a kidney condition called glomerulonephritis have higher mortality rates than those without this complication, a study shows. The condition affects 2 in every 100,000 inhabitants, researchers found in a population-based cohort in Minnesota. The study, “Incidence, prevalence, mortality and chronic renal…
A case report of a patient with eosinophilic granulomatosis with polyangiitis (EGPA), with the disease affecting both the heart and lungs, suggests that Rituxan (rituximab) together with corticosteroids might be a successful therapeutic approach. The study, “Eosinophilic Granulomatosis With Polyangiitis and Cardiac Involvement: A Case Report,” appeared in…
Patients with dermatomyositis — a condition marked by muscle weakness and a distinctive skin rash — can develop acute kidney disease due to overlapping autoimmune diseases affecting the small vessels, a case report shows for the first time. The patient described in the report developed both anti-glomerular basement membrane…
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