Japanese Team Suggests Activin A as New Biomarker for Renal Damage in AAV Patients

Measuring the levels of activin A protein in the urine can help clinicians identify patients who have renal problems caused by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, Japanese researchers found. Additional studies are still warranted to shed light on the underlying role of activin A — a potential…

High levels of a small RNA molecule called miR-142-3p may impair the function of immune regulatory T-cells in people with granulomatosis with polyangiitis (GPA), a study has found. The study, “Increased miR-142-3p Expression Might Explain Reduced Regulatory T Cell Function in Granulomatosis With Polyangiitis,” was published…

The development of a population of mutated blood cells — a phenomenon called clonal hematopoiesis of indeterminate potential — is more frequent in ANCA-associated vasculitis (AAV) patients than in healthy people, and may modify the clinical outcomes of the disease, a study reports. Some patients with such blood cell populations…

Allison Lint Ross looked like a typical healthy 16-year-old when she suddenly began to experience breathing difficulties, weakness, and disorientation that landed her in the emergency room. The talented violinist nearly died that day in 2004. Doctors discovered a lung hemorrhage and signs that her body was shutting…

ANCA-associated vasculitis (AAV) can cause recurrent bleeding in the lungs, which manifest as hemosiderosis — an excessive accumulation of iron deposits in tissues — and lung nodules, a case report suggests. The study, “Pathological and Radiological Correlation in Prolonged Myeloperoxidase Anti-neutrophil Cytoplasmic Antibody-related Diffuse Alveolar Hemosiderosis,”…

Administering rituximab repeatedly may improve the response of patients with ANCA-associated vasculitis (AAV) to the medication, a study says. The findings were reported in the study, “Non‐Linear Rituximab Pharmacokinetics and Complex Relationship between Rituximab Concentrations and Anti‐Neutrophil Cytoplasmic Antibodies (ANCA) in ANCA‐Associated Vasculitis: The RAVE Trial Revisited,”…

Infection is a common complication of ANCA-associated vasculitis (AAV) that tends to develop within six months of diagnosis, and in cases of  “mixed” infections — those caused by more than one type of bacteria, or by bacteria and fungi — can take a major toll on survival, a study…

ANCA-associated vasculitis (AAV) with childhood onset often affects multiple organs, showing symptoms at diagnosis in the ear, nose, and throat, as well as pulmonary and renal complications, a single-center study shows. Also, researchers found, rituximab appears to be effective at inducing and maintaining remission in pediatric AAV patients.

Adding methylprednisolone pulse therapy to standard induction therapy does not appear to have any particular benefit for people with severe ANCA-associated vasculitis (AAV) who need dialysis, a study suggests. The study, “The effect of pulse methylprednisolone induction therapy in Chinese patients with dialysis-dependent MPO-ANCA associated…

People with ANCA-associated vasculitis (AAV) are much more likely to develop a type of skin cancer called squamous cell carcinoma — nearly 13 times more likely — than those without this disease, a population-based study from Sweden reports. Other cancers, especially bladder and pancreatic cancer, were also more frequent…