Margarida Maia, PhD,  science writer—

A graphic prediction tool may accurately estimate the chance of survival over two years in people ANCA-associated vasculitis (AAV), according to a study at a single Chinese hospital. The tool, a nomogram based on 16 predictive factors, was able to differentiate patients who survived from those who didn’t with…

Physicians typically do not overestimate the overall health of people with ANCA-associated vasculitis (AAV), a study of global assessments made by patients and their doctors in Australia reports. In cases where ratings between these two groups markedly differed, doctors tended to assign a lower score than did the people…

Adicet Bio has pushed to the second half of 2025 the expected timing for enrolling patients with ANCA-associated vasculitis (AAV) in an ongoing Phase 1 clinical trial testing ADI-001, an experimental CAR T-cell therapy for a number of autoimmune diseases. The company had said it expected enrollment…

More than half of the people living with ANCA-associated vasculitis (AAV) have infections caused by bacteria, fungi, or viruses, often in the respiratory tract, with more than one-third developing severe infections. That’s according to a meta-analysis of published data, which also identified several risk factors for infections in this…

Q32 Bio is delaying the start of a planned Phase 2 clinical trial designed to test its ADX-097 therapy candidate in people with ANCA-associated vasculitis (AAV). The trial had been expected to begin in 2025. While details on that planned Phase 2 trial in AAV patients had…

Being frail, that is, more vulnerable to health stressors as a result of aging-related biological changes, may put older adults with ANCA-associated vasculitis (AAV) at higher risk of developing severe infections, a study in the U.S. suggests. Being age 75 or older, but not frail, was linked to a…

People with ANCA-associated vasculitis (AAV) who carry certain variants in SERPINA1 — a gene that’s been previously linked to the autoimmune disease — may have a six times higher risk of death than those without such variants. That’s according to new data from a single-center study in Brazil, in…

Low blood levels of glial fibrillary acidic protein (GFAP) are linked to more active disease and a higher risk of kidney failure in newly diagnosed ANCA-associated vasculitis (AAV), a study finds. The findings point to GFAP as a potential blood biomarker to predict the course of AAV early and…

Combination maintenance therapy with Nucala (mepolizumab) and azathioprine may be more effective than either treatment alone at maintaining disease remission and reducing the need for glucocorticoids in people with severe eosinophilic granulomatosis with polyangiitis (EGPA). These are the findings of a single-center study in Japan that support the use…

Tavneos (avacopan) effectively induces disease remission in adults with ANCA-associated vasculitis (AAV) and diffuse alveolar hemorrhage (DAH), that is, bleeding from the small blood vessels in the lungs, according to a real-world study in the U.S. The therapy also let all patients reduce their dose of glucocorticoids, a…