Author Archives: Joana Carvalho

Small Particles Produced by Platelets May Worsen Inflammation in AAV, Study Contends

Platelet-derived microparticles (PMPs) — small particles produced and released by platelets in the blood — may worsen inflammation in patients with ANCA-associated vasculitis, according to a recent study. The findings of the study, “Platelets release proinflammatory microparticles in anti-neutrophil cytoplasmic antibody-associated vasculitis,” were published in Rheumatology.

Abnormal Antimicrobial Traps in Lesions May Be Linked to AAV Development, Study Says

Abnormal antimicrobial traps found in inflammatory lesions from ANCA-associated vasculitis patients might be correlated with disease development, a study suggests. The study, “The formation and disordered degradation of neutrophil extracellular traps in necrotizing lesions of anti-neutrophil cytoplasmic antibody–associated vasculitis,” was published in The American Journal of Pathology.

Woman with Double-Positive Disease Treated with Plasma Exchange Combo, Case Study Shows

A woman in Japan diagnosed with both ANCA-associated vasculitis and anti-glomerular basement membrane (GBM) disease — an extremely rare medical condition known as double-positive disease — was successfully treated with plasma exchange and cyclophosphamide,  according to a case report. The case study, “Successful treatment of steroid-refractory double-positive ANCA and…