Joana Carvalho, PhD, managing science editor —

Joana holds a bachelor’s in biology, a Master of Science in evolutionary and developmental biology, and a PhD in biomedical sciences from Universidade de Lisboa, Portugal. Her work has been focused on the impact of non-canonical Wnt signaling in the collective behavior of endothelial cells — those that make up the lining of blood vessels — found in the umbilical cord of newborns. In addition to several research fellowships, she was awarded two Erasmus scholarships to conduct part of her studies in France.

Articles by Joana Carvalho

Small Particles Produced by Platelets May Worsen Inflammation in AAV, Study Contends

Platelet-derived microparticles (PMPs) — small particles produced and released by platelets in the blood — may worsen inflammation in patients with ANCA-associated vasculitis, according to a recent study. The findings of the study, “Platelets release proinflammatory microparticles in anti-neutrophil cytoplasmic antibody-associated vasculitis,” were published in Rheumatology.

Abnormal Antimicrobial Traps in Lesions May Be Linked to AAV Development, Study Says

Abnormal antimicrobial traps found in inflammatory lesions from ANCA-associated vasculitis patients might be correlated with disease development, a study suggests. The study, “The formation and disordered degradation of neutrophil extracellular traps in necrotizing lesions of anti-neutrophil cytoplasmic antibody–associated vasculitis,” was published in The American Journal of Pathology.

Rituxan’s Efficacy May Be Linked to It Blocking How B-cells and Certain T-cells Interact, Study Says

Blocking the interaction between immune B-cells and CD8-positive T-cells may be what makes Rituxan (rituximab) an effective treatment for ANCA-associated vasculitis (AAV), a study reports. Findings of the study, “B cell depletion therapy dampens CD8+ T cell response in ANCA‐associated vasculitis,” were published in Arthritis & Rheumatology.

Woman with Double-Positive Disease Treated with Plasma Exchange Combo, Case Study Shows

A woman in Japan diagnosed with both ANCA-associated vasculitis and anti-glomerular basement membrane (GBM) disease — an extremely rare medical condition known as double-positive disease — was successfully treated with plasma exchange and cyclophosphamide,  according to a case report. The case study, “Successful treatment of steroid-refractory double-positive ANCA and…