Blood levels of CCL23, an immune molecule that may be involved in blood vessel formation and repair, are significantly increased in people with ANCA-associated vasculitis (AAV) relative to healthy people, a study finds. High blood CCL23 levels accurately differentiate people with active AAV from those in remission and increase…
Blood levels of a signaling molecule called growth differentiation factor 15 (GDF15) at diagnosis may help predict poor outcomes, including kidney failure and death, in people with ANCA-associated vasculitis (AAV), according to a study in South Korea. Data also showed that GDF15 levels were significantly associated with AAV…
People with ANCA-associated vasculitis (AAV) have significantly higher blood levels of C4d, a protein that reflects activation of the classic or lectin complement pathways of the immune system, a study in Sweden suggests. Patients with self-reactive antibodies, called ANCAs, against the proteinase-3 (PR3) protein had significantly higher blood Cd4…
Lower blood levels of glutathione peroxidase-3 (GPX-3), an antioxidant enzyme, are significantly associated with greater disease activity and blood vessel damage in people with ANCA-associated vasculitis (AAV), a study found. “We demonstrated that [blood] GPX-3 concentration at diagnosis has the potential to be a novel biomarker that can assess…
People with ANCA-associated vasculitis (AAV) patients whoo have low blood levels of sulfatides, a type of fatty molecule, are significantly more likely to have future kidney failure, a single-center study in South Korea indicates. The predictive potential of blood sulfatide levels was independent of direct associations with kidney involvement…
Eosinophilic granulomatosis with polyangiitis (EGPA) patients treated at private practices in the U.S. have high disease burden associated with multiple symptoms and simultaneous health conditions, a study showed, mirroring findings reported for patients treated at academic settings. Patients treated in private practice demonstrated variable responses to standard treatments, with some patients…
Most children with ANCA-associated vasculitis (AAV) and kidney involvement at diagnosis will exhibit inactive kidney disease after one year, and more than two in five will show evidence of permanent kidney damage, according to data from an international registry study. A glomerular filtration rate (eGFR) — a standard measure…
A reduced glucocorticoid dosing regimen for inducing disease remission in people with ANCA-associated vasculitis (AAV) may be associated with a higher risk of poor disease outcomes in those with severe disease, compared with the standard-dose regimen. That’s according to a real-world study in France and Luxembourg that involved people…
Eosinophilic granulomatosis with polyangiitis (EGPA) should be considered in people with uncontrolled severe asthma and high blood levels of immune cells called eosinophils — a hallmark of the autoimmune disease — according to the findings of a study from Singapore. This rare type of ANCA-associated vasculitis (AAV) was…
Most children with granulomatosis with polyangiitis (GPA) have respiratory manifestations including cough and shortness of breath at diagnosis, and these frequently persist or relapse, according to a study in the U.S. involving 13 pediatric patients. Lung abnormalities were detected in nearly all children with available imaging data at diagnosis…
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