Older age, being male, smoking history, and having self-reactive antibodies targeting the myeloperoxidase (MPO) protein are significantly associated with a higher risk of interstitial lung disease (ILD) in people with ANCA-associated vasculitis (AAV). That’s according to a review and meta-analysis study, which also showed that certain imaging signs of…
People with ANCA-associated vasculitis (AAV) who test positive for a staining pattern of self-reactive antibodies called cytoplasmic ANCA (C-ANCAs) are nearly five times more likely to have bleeding into the lungs’ air sacs, known as alveolar hemorrhage, a study found. C-ANCA is marked by the presence of ANCAs —…
In people with eosinophilic granulomatosis with polyangiitis (EGPA), those with skin or heart involvement have significantly higher blood levels of immunoglobulin E (IgE), a type of natural antibody frequently linked to EGPA, a study showed. Testing positive for the self-reactive antibodies ANCAs against the myeloperoxidase (MPO) protein tended to…
A protein known as NGAL — fully, neutrophil gelatinase-associated lipocalin — appears to be a marker of disease activity and kidney damage severity in people with ANCA-associated vasculitis (AAV) who have kidney inflammation, according to new research by scientists in China. The team found that “in active AAV, [blood]…
Two Phase 1/2 clinical trials testing NKX019 — Nkarta’s cell therapy candidate — are now enrolling participants to test a second, higher dose in people with ANCA-associated vasculitis (AAV) and other autoimmune conditions. The Ntrust-2 study (NCT06733935) is enrolling up to 144 people with AAV, idiopathic inflammatory…
People with ANCA-associated vasculitis (AAV) are at a higher risk of developing nonmelanoma skin cancer (NMSC), the most common form of skin cancer, but not other types of cancer, according to a long-term follow-up study in Europe. The use of the immunosuppressive therapy azathioprine, longer azathioprine treatment, and being…
Being male, being 55 or older, having evidence of kidney damage, and having nervous system involvement are independently associated with a higher risk of relapse and death in people with granulomatosis with polyangiitis (GPA), according to a study in Iran. “Awareness of this information can lead to better understanding…
Treatment with Tavneos (avacopan) appeared to more effectively suppress organ damage — while also significantly lowering glucocorticoid dosages and associated adverse events — in people with ANCA-associated vasculitis (AAV), according to a real-world study in Japan. The study looked at the safety and effectiveness of glucocorticoids plus rituximab…
Preliminary data from a Phase 1 clinical trial testing NKX019, Nkarta’s cell therapy candidate for ANCA-associated vasculitis (AAV) and other autoimmune conditions, are expected in the second half of this year. That’s according to a mid-year update from the biotechnology company, which is developing the natural killer (NK) cell…
People with ANCA-associated vasculitis (AAV) affecting the kidneys who receive kidney transplants face higher long-term risks of transplant failure and death compared with those who undergo transplants for other reasons. That’s according to a study from France, which also found that the presence of ANCAs — self-reactive antibodies that…
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