News

The U.S. Food and Drug Administration has approved two automated diagnostic tests that AESKU.Group developed for ANCA-associated vasculitis. AESKU used its HELIOS technology to develop the tests. HELIOS is the only diagnostic tool capable of both processing and analyzing a patient’s blood sample via an immunofluorescence assay (IFA) in a single run, the…

ANCA-associated vasculitis (AAV) may be associated with rare mutations in the alpha-1 antitrypsin (AAT) protein, a new case report suggests. The study, “Fulminant hepatic failure in the setting of progressive ANCA-associated vasculitis associated with a rare alpha-1 antitrypsin phenotype, ‘PiEE‘,” was published in the journal BMJ…

Patients with ANCA-associated vasculitis carry a threefold higher risk for cardiovascular disease, and a eightfold greater risk for cerebrovascular accidents, compared to the general population, a long-term study shows. The study, “Risk of Cardiovascular Disease and Venous Thromboembolism Among Patients With Incident ANCA-Associated Vasculitis: A 20-Year Population-Based Cohort…

Patients with ANCA-associated vasculitis might develop acute thrombocytopenia — extremely low levels of platelets circulating in the blood — after being treated with Rituxan (rituximab), a case study from Japan reported for a first time. While rare, physicians should be aware of this potential side effect so as to detect…

Patients with ANCA-associated vasculitis (AAV) have a higher prevalence of thyroid disease than the general population, a single-center retrospective analysis shows. But the increase in thyroid disease is not related to the use of anti-thyroid medications, researchers said. The study, “Increased Prevalence of Thyroid Disease in…

Eosinophilic granulomatosis with polyangiitis (EGPA) may manifest as as a painful, progressive skin rash, and be associated with secondary cryoglobulinemia — a condition where abnormal proteins in the blood clump together at low temperatures — a new case report shows. While rare, it is critical that these conditions are recognized…

Chest manifestations and disease activity at diagnosis may help predict the risk of  infections during hospital stays in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), a retrospective study suggests. The South Korean study, “Birmingham vasculitis activity and chest manifestation at diagnosis can predict hospitalised infection in ANCA-associated vasculitis,”…

Granulomatosis with polyangiitis (GPA) may sometimes manifest as facial paralysis and ear pain — a potentially challenging diagnosis, according to the case report of a teenage patient. The study, “Granulomatosis with polyangiitis presenting as facial nerve palsy in a teenager,” appeared in the International Journal of Pediatric…

Classifying the specificity of ANCA autoantibodies may complement the currently used clinical classification system when predicting the course of disease and prognosis in ANCA-associated vasculitis (AAV) patients with renal involvement, according to Spanish researchers. Indeed, ANCA specificity was seen to be better at predicting relapse than clinical classification.

Patients with ANCA-associated glomerulonephritis receiving immunosuppressive therapy are not more likely to develop cancer than the general population, a study found. However, researchers did find that the risk for blood, post-transplant, and nonmelanoma skin cancers (NMSC) is higher among these patients. Findings were reported in the study,…