Tavneos (avacopan) plus a short course of glucocorticoids is as effective as glucocorticoids alone for treating rapidly progressive glomerulonephritis (RPGN), a severe kidney disease, in adults with ANCA-associated vasculitis (AAV), a study reports. “At month 6, patients receiving [Tavneos] and transient or low doses of GCs [glucocorticoids] have…
Four proteins in the kidneys likely contribute to the development of ANCA-associated vasculitis (AAV), and may be used as diagnostic markers and targets of potential therapies, a study found. The proteins — PDK4, PPARGC1A, FN1, and PSMB10 — are “novel biomarkers that may refine our understanding and management of AAV,”…
A low-dose course of glucocorticoid therapy results in similar outcomes as a higher-dose option in people with ANCA-associated vasculitis (AAV) and kidney involvement, though it may lower risk of serious infection, a study reports. “Our findings reinforce the safety and efficacy of reduced [glucocorticoid] as the initial [glucocorticoid] regimen…
Combining two diagnostic systems used to classify cases of ANCA-associated vasculitis (AAV) in adults improved classification performance in a pediatric AAV patient population, according to a study in China. Identifying types of AAV is important to ensure effective clinical care in children, researchers noted. “Considering that distinct clinical…
Alivedx’s Mosaiq Aiplex vasculitis assay, a platform test for the two main self-reactive antibodies that drive most cases of ANCA-associated vasculitis (AAV), is now available for clinical use in the European Union (EU). The test is also able to detect self-reactive antibodies linked to another autoimmune condition marked…
In ANCA-associated vasculitis (AAV), the involvement of the central nervous system (CNS), that is, the brain and spinal cord, is uncommon, but other factors may mimic CNS involvement, a study reports. These so-called mimickers can include AAV disease processes not related to the CNS, other conditions, and drug-related adverse…
Note: This story was updated on Aug. 6, 2025, to correct that proteinase 3 (PR3) and myeloperoxidase (MPO) are the enzymes targeted by AAV-causing antibodies. People with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis have elevated levels of certain immune-related proteins in their blood, a new study from Sweden reports. However, different…
Ratios of different kinds of blood cells, reflecting inflammation and immune activity, may be a cheap and efficient tool to aid in the diagnosis of ANCA-associated vasculitis (AAV), and in predicting disease activity, a new study from China reports. “While not standalone diagnostic tools, these markers offer valuable support…
The most common neurological symptoms of ANCA-associated vasculitis (AAV) among patients in a single center in Columbia — regardless of disease type — were headache and objective signs of damage to nerves outside the brain and spinal cord, a study showed. That said, the researchers found a vast array…
ANCA-associated vasculitis (AAV) therapy Tavneos (avacopan) is at least as effective as the glucocorticoid prednisone at inducing disease remission, reducing relapse rates, and improving kidney function and quality of life in patients with kidney involvement at treatment start. That’s according to new subgroup analyses from the Phase…
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