Author Archives: Forest Ray PhD

EGPA Symptoms More Pronounced in ANCA-positive Cases

Symptoms differ among people with the rare disorder eosinophilic granulomatosis with polyangiitis (EGPA), depending on whether they test positive or negative for antineutrophil cytoplasmic antibodies (ANCAs). A recent case study revealed that ANCA-positive patients tended to have more blisters, body-wide inflammatory symptoms, and to receive higher doses of oral…

New Guidelines May Help Take Guesswork Out of Treating AAV

The American College of Rheumatology and the Vasculitis Foundation have published new guidelines to improve the treatment and management of systemic vasculitis, a group of inflammatory disorders that includes ANCA-associated vasculitis (AAV). The rarity of these disorders can make them challenging to diagnose and treat. The new…

Vilobelimab Safe, Well-tolerated in Phase 2 IXPLORE Study

Adding vilobelimab (IFX-1) to standard of care treatment is safe and well-tolerated among patients with ANCA-associated vasculitis (AAV), according to top-line results from the ongoing Phase 2 IXPLORE study. Some participants also showed clinical response and remission, although the study was not designed to assess the statistical significance…

AAV Transplant Recipients More Often Die With Functioning Kidney

Kidney transplant recipients, whose kidney failure stemmed from ANCA-associated vasculitis (AAV), have less risk of disease recurrence but a higher risk of dying with a functioning transplant,  a recent study suggests. These patients also had a higher risk of dying from complications due to immunosuppression and infection. The study,…