Author Archives: Ashraf Malhas, PhD

Early Diagnosis of AAV Symptoms Decreases Risk of Renal Damage, Mortality

A retrospective study has found an association between the length of prodromal phase – where patients experience non-specific symptoms before more specific disease signs develop – and mortality in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients. This finding underscores the importance of early diagnosis. The study, “Relation…

Organ Involvement in AAV Patients Better Than Disease Type at Predicting Survival Outcomes, Study Suggests

Classifying patients with anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) based on organ involvement at the time patients are first examined has stronger correlation with survival rates, than the customary classification based on disease phenotype, a study has found. The study, “Long-term patient survival in a Swedish population-based cohort…

Methotrexate Effective for ANCA-Associated Vasculitis Remission Maintenance Treatment, Study Finds

Methotrexate is an effective and safe option for remission maintenance therapy in patients with anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), a study has found. The study, “Methotrexate versus cyclophosphamide for remission maintenance in ANCA-associated vasculitis: A randomised trial,” was published in the journal Plos One. AAV…

Extended Azathioprine Maintenance Therapy Doesn’t Prevent Relapse in AAV Patients, Study Finds

Long-term maintenance therapy with azathioprine (AZA) does not improve relapse rates in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), according to researchers. The study, “Long term azathioprine maintenance therapy in ANCA-associated vasculitis: combined results of long-term follow-up data,” was published in the journal…

Changes in Circulating Immune Cells in AAV Linked to Kidney Damage

Although certain immune cells are present at lower levels in patients with anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), it is due to non-specific renal injury rather than the disease itself, study shows. The study, “Alterations in circulating lymphoid cell populations in systemic small vessel vasculitis are non-specific…

ANCA–Associated Vasculitis Occurs in Ethnic Groups Differently, Study Finds

Different types of ANCA-associated vasculitis occur in different ethnic groups, a study reports. The research, “Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody􏰀associated vasculitis,” was published in the journal Rheumatology. Anti-neutrophil cytoplasm antibodies-associated vasculitis, or AAV, refers to three…

Central Nervous System Involvement Seen Not to Affect Survival Rates in GPA Patients, Study Finds

A retrospective study has investigated the central nervous system’s (CNS) involvement in granulomatosis with polyangiitis (GPA) in a group of Greek patients. The study found that CNS involvement does not affect long-term patient outcomes. ANCA-associated vasculitis (AAV) refers to a group of rare diseases characterized by inflammatory cell infiltration and…