Alice Melão,  —

In rare cases, people with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis may also have symptoms of a chronic liver disease called primary biliary cirrhosis, a case report shows. To date, only six other cases of these overlapping conditions have been reported in the literature, so researchers have not been able to…

Denosumab, an approved treatment for osteoporosis, may sometimes trigger antineutrophil cytoplasmic antibody (ANCA) associated vasculitis with cytoplasmic ANCAs, a case study reports. While this treatment has been linked with vasculitis, this is the first report of a denosumab-derived cytoplasmic-ANCA vasculitis, the researchers say. The case study, “c-ANCA vasculitis…

In rare cases, eosinophilic granulomatosis with polyangiitis (EGPA) may serve as a trigger for thrombotic microangiopathy (TMA), a disease that affects the smallest blood vessels in the body and often involves blood clots, a case report suggests. It remains unclear why these two rare disorders may be interconnected. However, a common underlying…

Pain and swelling in the testes, in rare cases, may be the first symptoms of ANCA-associated vasculitis, even among patients without other symptoms associated with this disease, researchers reported, noting that testicular vasculitis is often misdiagnosed. The study, “Testicular granulomatous vasculitis mimicking testicular torsion in an anti-neutrophil…

PredictImmune has expanded its intellectual propriety portfolio with a new patent approved in Canada covering the company’s methods for predicting the risk of progression among patients with autoimmune diseases, like ANCA-associated vasculitis (AAV) and inflammatory bowel disease (IBD). This follows the 2018 approval of previous patent applications…

In light of upcoming Phase 3 data, ChemoCentryx and Vifor Fresenius Medical Care Renal Pharma have decided not to pursue the conditional approval of avacopan in Europe for patients with ANCA-associated vasculitis. Instead, the companies plan to submit a full (unconditional) marketing approval application for the therapy in 2020 with…

Impaired renal function, the presence of ANCA antibodies against the MPO protein, and a score of 2 or higher in the five-factor score — which measures prognosis at diagnosis in ANCA-associated vasculitis (AAV) — are all potential predictors of poor renal outcomes in children with AAV, a study has found.

Blood vessel inflammation caused by ANCA antibodies should be considered in the differential diagnosis of familial Mediterranean fever with hyperthyroidism, a case study shows. The study, “Antineutrophil cytoplasmic antibody-positive familial Mediterranean fever and hyperthyroidism: A case report,” was published in the journal Medicine. Familial Mediterranean…

Researchers reported for the first time the case of a patient with ANCA-associated vasculitis whose condition caused bleeding in the brain and spinal cord, most likely because of a ruptured aneurysm. The study, “Anti-neutrophil cytoplasmic antibody associated central nervous system vasculitis with brain and spinal cord subarachnoid…

Early identification of granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA) overlap is critical for prognosis, long-term treatment, and management of these two distinct diseases, a case report shows. Although few instances of this rare event have been reported, clinicians should be aware of this possibility…