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September 24, 2019

GPA Management Should Not Be Based on ANCA Levels Alone, Study Suggests

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In granulomatosis with polyangiits (GPA) patients, the levels of anti-neutrophil cytoplasmic autoantibodies (ANCAs) — the autoantibodies associated with the condition — appear to correlate with worse disease activity, a ... Read more

September 23, 2019

Risk Factors for Deep-vein and Other Blood Clots in AAV Patients ID’d in Study

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People with ANCA-associated vasculitis (AAV) are at a greater risk of venous thromboembolism — blood clots in veins — if they have evidence of bleeding into the lungs, heart ... Read more

September 19, 2019

Neurological Symptoms in AAV Patients Do Not Impact Likely Long-term Survival, Study Reports

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Almost half of patients diagnosed with ANCA-associated vasculitis (AAV) showed neurological symptoms in a single-site, retrospective study from India. But while nervous system involvement appears to be more common than ... Read more

September 17, 2019

Lung Ultrasound Accurately Detects Lesions in AAV, Study Shows

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Lesions in the lungs caused by ANCA-associated vasculitis (AAV) are variable among patients, but lung ultrasound appears to be as good as computed tomography (CT) scans at detecting them, ... Read more

September 16, 2019

Small Particles May Serve as Blood Biomarker of Kidney Problems in AAV, Study Suggests

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ANCA-associated vasculitis (AAV) patients with renal involvement have higher blood levels of certain small vesicles than either patients without kidney symptoms or people without this disease, a study found. ... Read more

September 12, 2019September 30, 2019

AAV and Lupus in Woman with Unusual Kidney Damage Described in Case Report

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Different autoimmune pathways — which determine how autoantibodies affect the body — might be involved in cases of lupus nephritis that are positive for ANCAs, leading to unusual kidney ... Read more

September 10, 2019

New Mouse Model of AAV May Reveal Role of Specific DNA Regions

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A new mouse model of ANCA-associated vasculitis (AAV) shows glomerulonephritis, lung vasculitis, and MPO-ANCA autoantibodies, among other alterations seen in patients with the disease. These mice may help determine ... Read more

September 9, 2019

Study Identifies AAV-associated Genetic Variants in Chinese Population

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Variants in immune-related genes may make certain people more or less susceptible to anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV), a new study suggests. The study, “Risk HLA class II ... Read more

September 5, 2019

Isolated Acute Sinusitis Might Indicate GPA, Case Report Suggests

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Doctors should suspect granulomatosis with polyangiitis (GPA) in cases of isolated, acute sinusitis that does not improve with treatment, especially in young patients, a case report suggests. The study, ... Read more

September 3, 2019

New Index Calculates AAV Severity at Diagnosis and Predicts Mortality, Study Says

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Researchers have developed a specific index for ANCA-associated vasculitis (AAV) that uses laboratory results at the time of diagnosis to help assess disease activity and predict death by any ... Read more

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