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November 27, 2019November 27, 2019

Avacopan Shows Superiority Over Steroids to Treat AAV in Phase 3 ADVOCATE Trial

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Avacopan (CCX168) can effectively improve remission rates, kidney function, and overall quality of life of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), compared with standard therapy with steroids, ... Read more

November 25, 2019November 26, 2019

Smoking Raises Person’s Risk of AAV, Large US Study Suggests

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Being a former or current cigarette smoker significantly increases the risk of developing ANCA-associated vasculitis (AAV), data from a large U.S. study show. This association was particularly strong in ... Read more

November 20, 2019November 20, 2019

High-dose Glucocorticoids Common for AAV Patients in Europe, But Response Is Limited, Study Reports

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High-dose glucocorticoids — a type of corticosteroid hormone — are commonly prescribed as part of remission-induction therapy to people with ANCA-associated vasculitis (AAV) in Europe, a retrospective study reports. ... Read more

November 13, 2019

Rare Disease Film Festival Highlights Patient and Researcher Unity

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Rare disease-themed videos glowed on a large screen before an audience of people in wheelchairs, with crutches, and bearing oxygen tanks this Nov. 9 and 10 in San Francisco. ... Read more

November 11, 2019November 11, 2019

Patients With SLE, GPA Have High Long-Term Survival Rates After Kidney Transplant, Study Shows

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People with systemic lupus erythematosus (SLE) or granulomatosis with polyangiitis (GPA) who undergo kidney transplants have high survival rates over the long term without evidence of an increased risk ... Read more

November 6, 2019November 6, 2019

ANCA-Associated Vasculitis can Result in Appendicitis Without Other Systemic Symptoms, Case Report Shows

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Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis can result in inflammation of the appendix — commonly known as appendicitis — without any additional systemic symptoms, researchers report for the first time. ... Read more

November 4, 2019November 4, 2019

Fewer Relapses, Lower Steroid Doses After Dialysis in Japanese AAV Patients, Study Reports

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Dialysis for Japanese patients with kidney disease triggered by ANCA-associated vasculitis led to fewer life-threatening relapses and reduced doses of immunosuppressive steroids, a long-term study suggests. The study, “Long‑term follow‑up ... Read more

October 30, 2019October 30, 2019

Japanese Team Suggests Activin A as New Biomarker for Renal Damage in AAV Patients

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Measuring the levels of activin A protein in the urine can help clinicians identify patients who have renal problems caused by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, Japanese researchers found. ... Read more

October 28, 2019October 28, 2019

Small RNA Molecule miR-142-3p May Impair Immune T-Cell Function in GPA, Study Finds

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High levels of a small RNA molecule called miR-142-3p may impair the function of immune regulatory T-cells in people with granulomatosis with polyangiitis (GPA), a study has found. The ... Read more

October 22, 2019

Mutant Blood Cells Relatively Common in AAV Patients and Carry Risks and Benefits, Study Suggests

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The development of a population of mutated blood cells — a phenomenon called clonal hematopoiesis of indeterminate potential — is more frequent in ANCA-associated vasculitis (AAV) patients than in healthy people, ... Read more

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