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August 1, 2019

Rare Disease Groups Seek Public Support to Renew Newborn Screening Act in Senate

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Screening newborns for genetic diseases with treatments that can prevent crippling or deadly progression, especially for rare disorders, has a ways to go in the United States. No state ... Read more

August 1, 2019

Levels of Rheumatoid Factor May Mark Two Distinct Types of EGPA, Study Says

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Levels of rheumatoid factor — an antibody against healthy tissue found in some autoimmune diseases — appear to separate eosinophilic granulomatosis with polyangiitis (EGPA) patients into two subtypes with ... Read more

July 30, 2019

FDA Approves Rituxan Biosimilar Ruxience for 2 ANCA Vasculitis Subtypes

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The U.S. Food and Drug Administration (FDA) has approved Pfizer‘s Ruxience (rituximab-pvvr), a biosimilar to Rituxan (rituximab), as a treatment for granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) ... Read more

July 29, 2019

Interleukin-6 Levels Predict Severe Relapses in ANCA Vasculitis Patients on Rituximab, Study Reports

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Although serum levels of the pro-inflammatory molecule interleukin (IL)-6 do not predict who will achieve complete remission, increases during periods of no disease activity are associated with subsequent severe ... Read more

July 25, 2019

Antimicrobial Traps in AAV Patients Differ From Those With SLE, Study Says

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The formation, composition, and structure of antimicrobial traps in ANCA-associated vasculitis (AAV) patients are markedly different from those with systemic lupus erythematosus (SLE), a study says. The findings of ... Read more

July 23, 2019

Alterations in Kidney Cells Could Predict Excess Protein in Urine, Study Suggests

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Measuring structural features of specialized kidney cells called podocytes could predict short-term proteinuria — excess proteins in urine — in patients with ANCA-associated glomerulonephritis, according to a new study. ... Read more

July 22, 2019

Inflammatory Proteins May Serve as Biomarkers of Early Disease, Kidney Damage in AAV, Study Suggests

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Determining the levels of interleukins in the blood, specifically IL-10 and IL-33, may help identify people with early systemic ANCA-associated vasculitis, and those at risk of kidney damage, a ... Read more

July 19, 2019July 18, 2019

European Initiative Targets Diagnosis, Treatment of Rare Diseases

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A new international consortium based in Paris, and funded largely by the 28-member European Union, intends to speed the diagnosis of rare diseases, while also accelerating the development of ... Read more

July 18, 2019

Fluid Buildup Around Heart Leads to Finding of Vasculitis Subtype EPGA, Case Study Reports

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Cardiac tamponade, the buildup of fluid in the space surrounding the heart, revealed a case of eosinophilic granulomatosis with polyangiitis (EGPA) that was successfully treated with prednisolone and a ... Read more

July 16, 2019

High Blood Pressure and Other Cardiovascular Risks Prevalent in ANCA Vasculitis Patients, Researchers Say

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High blood pressure and other cardiovascular risk factors are highly prevalent in people with ANCA-associated vasculitis (AAV), and a sizable number — more than one-third — of patients are ... Read more

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