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March 25, 2019

Interleukin-21 Levels May Indicate Disease Activity in AAV Patients, Pilot Study Suggests

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High blood levels of a signaling molecule called interleukin-21, or IL-21, may identify patients with active ANCA-associated vasculitis (AVV), a pilot study suggests. The study, “Serum interleukin-21 positivity could ... Read more

March 21, 2019

Eye Problems May Be Early GPA Symptom; Rituxan Helps in Recurrent Cases

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Eye problems are a common symptom of granulomatosis with polyangiitis, of which clinicians should be aware as it can be an initial symptom of the disease, a study reports. Most ... Read more

March 19, 2019

Case Report Describes Rare Coexistence of Chronic Liver Condition and MPA

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In rare cases, people with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis may also have symptoms of a chronic liver disease called primary biliary cirrhosis, a case report shows. To date, only six ... Read more

March 18, 2019March 18, 2019

Osteoporosis Treatment Denosumab May Cause ANCA Vasculitis, Case Report Suggests

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Denosumab, an approved treatment for osteoporosis, may sometimes trigger antineutrophil cytoplasmic antibody (ANCA) associated vasculitis with cytoplasmic ANCAs, a case study reports. While this treatment has been linked with vasculitis, ... Read more

March 15, 2019March 14, 2019

Brexit Could Have Real Effects for UK Rare Disease Patients, Experts Warn

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Madeline Collin, a 24-year-old activist with Gaucher disease, worries that patients like her will suffer deeply if Britain leaves the European Union (EU), as scheduled, at the end of ... Read more

March 14, 2019

Small Particles Produced by Platelets May Worsen Inflammation in AAV, Study Contends

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Platelet-derived microparticles (PMPs) — small particles produced and released by platelets in the blood — may worsen inflammation in patients with ANCA-associated vasculitis, according to a recent study. The findings of ... Read more

March 13, 2019March 11, 2019

Moral Dilemmas Complicate Treatment of Rare Diseases, Says Israeli Bioethicist

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With each new advance in medicine comes ethical dilemmas, from fertility treatments and newborn screening, to vaccinations, gene therapies and euthanasia. But rare diseases and the expensive therapies needed ... Read more

March 12, 2019March 12, 2019

Dividing AAV According to Antibodies Provides No Further Benefit for Prognosis, Study Reports

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Dividing ANCA-associated vasculitis (AAV) into subgroups defined by type of antibodies does not provide additional value for clinical prognosis, according to recent research. The study, “Clinical impact of subgrouping ANCA-associated ... Read more

March 11, 2019

Rise in MPO-ANCA Antibodies After Remission May Predict Relapse

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Among ANCA-associated vasculitis patients in remission — particularly those with manifestations in their kidneys — the reappearance of MPO-ANCA antibodies may be a sign of disease relapse, a study ... Read more

March 7, 2019

Antibody Fragment May Be Used to Treat ANCA Vasculitis, Study Reports

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A piece of an antibody targeting a protein involved in cholesterol transport and metabolism might be an effective treatment for anti-neutrophil cytoplasmic autoantibodies (ANCA) vasculitis, a study suggests. The study, ... Read more

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